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. 2023 Feb 9;32(6):1595–1605. doi: 10.1007/s11136-022-03328-3

Table 1.

Final selection of PROs

PRO domain Specification Subdomains
Symptoms Fatigue Degree (intensity) of fatigue None
Pain Single item rating of degree (intensity) of pain None
Functioning Physical functioning Ability to perform everyday activities

1. Activities of daily living

2. Instrumental activities of daily living

3. Mobility

Participation in social roles Ability to participate in social roles and activities

1. Engaging in formal and informal relationships

2. Engaging in family roles

3. Engaging in domestic roles

4. Engaging in work or education related roles

5. General

Mental functioning Anxiety Experienced anxiety

1. Cognitive anxiety: Anticipating acute (fear) or future (anxiety) threats

2. Physiological anxiety: Experiencing anxiety related bodily sensations including increased heart rate and restlessness

Depression Experienced depressive symptoms

1. Dysphoria (sadness, irritability)

2. Anhedonia (loss of interest or pleasure in activities of daily living)

3. Disruption of vegetative functions (psychomotor retardation, insomnia, loss of appetite)

Overarching Perceived health Single item rating of perceived overall health None
Quality of life Single item rating of perceived overall quality of life None