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. 2023 May 10;13:7604. doi: 10.1038/s41598-023-34440-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of CFTR protein by immunofluorescence. (A) Representative images showing immunofluorescence detection of CFTR (red) in CFBE41o- cells expressing F508del-CFTR after 24 h treatment with vehicle (control), 1 µM VX-809, 10 µM PP028, and 1 µM VX-809 plus 10 µM PP028. Arrows show F508del-CFTR signal at the plasma membrane. Scale bar: 20 µm. (B) Intensity of CFTR signal in the perinuclear region of cells treated with indicated compounds. (C) Ratio of CFTR intensity signal in the peripheral and perinuclear regions. *, p < 0.05; ***, p < 0.001; vs. vehicle (ANOVA with Tukey’s post-hoc test).