Table 3.
Target therapy related with metabolite sensing in cancers
| Category | Effect target | Targeted medicine | Targeted effect | Ref./refs. |
|---|---|---|---|---|
| Glucose | GLUT | Phloretin | Inhibitor | 86 |
| Fasentin | 86 | |||
| STF-31 | 86 | |||
| WZB117 | 86 | |||
| Ritonavir | 86 | |||
| Silybin | 87 | |||
| HK | 2-DG | Inhibitor | 88,89 | |
| LN | Inhibitor | 90 | ||
| Resveratrol | Inhibitor | 91 | ||
| Astragalin | Antagonist | 92 | ||
| Chrysin | Antagonist | 93 | ||
| Genistein-27 | Antagonist | 94 | ||
| Benserazide | Inhibitor | 95 | ||
| PI3K/Akt | Afuresertib | Inhibitor | 96 | |
| Uprosertib | ||||
| Ipatasertib | ||||
| mTORC1/2 | PP242 | Inhibitor | 101 | |
| PI3K/mTOR | NVP-BEZ235 | Inhibitor | 102 | |
| Fatty acid | GPR109A | MK1903 | Antagonist | 141 |
| Acifran | 142 | |||
| 5-ANA | 143 | |||
| GSK256073 | 144 | |||
| Fatty acid β oxidation | Etomuslim | Antagonist | 136 | |
| Peroxicillin | ||||
| LDHA | FX11 | Inhibitor | 150,152 | |
|
N-hydroxy-2-carboxy-substituted indole compounds |
150,153 | |||
| GPR43 | 4-CMTB | Agonist | 167–170 | |
| AZ1729 | 167–170 | |||
| GPR84 | Compound 33 | Antagonist | 174 | |
| GLPG1205 | 175 | |||
| LY-237 | Agonist | 178 | ||
| 6-Octylaminouracil | 179 | |||
| GPR40 | GW100 | Antagonist | 184 | |
| DC260126 | 185 | |||
| GPR120 | AH7614 | Antagonist | 187,188 | |
| GW9508 | Agonist | 190 | ||
| TUG-891 | 192 | |||
| Compound 39 | 193 | |||
| GPR78 | Anti-CTD GPR78 antibody | Blocker | 197 | |
| miR-936 | Antagonist | 198 | ||
| HDAC | Vorinostat | Inhibitor | 223–225 | |
| Entinostat | 226 | |||
| Valproate | 227 | |||
| Romidepsin | 228 | |||
| CD44 | CD44 mono-antibody | Blocker | 256 | |
| 15-PGDH | HDAC inhibitors | Agonist | 269 | |
| Nonsteroidal anti-inflammatory drugs | ||||
| PPAR-γ agonists | ||||
| FASN | Cerulenin | Inhibitor | 278 | |
| ACSS2 | MTB-9655 | Inhibitor | NCT04990739 | |
| ACC1 | TOFA | Inhibitor | 285 | |
| ND-646 | 286,287 | |||
| Amino acid | mTOR | Temsirolimus | Inhibitor | 322 |
| eEF-2K | 323 | |||
| GPR109A | Niacin | Agonist | 324 | |
| GPR56 | Transglutaminase 2 | Inhibitor | 332 | |
| LGR5 | Agonist | 340 | ||
| Glutamine | ASCT2 | Agonist | 355 | |
| v-9302 | Inhibitor | 356 | ||
| Leucine | circFBXL5 | Agonist | 374 | |
| mTORC1 | EP300 | Agonist | 378 | |
| BCAT | BCAA | Agonist | 382,383 | |
| Serine | PKM2 | Agonist | 388 |