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. 2023 Apr 27;14:1181697. doi: 10.3389/fimmu.2023.1181697

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Copyright © 2023 She, Tan, Wang, Du, Zhou, Zhang, Du, Guo, Wu, Li, Bao, Mao, Hu, Liu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell gene expression analysis of peripheral blood mononuclear cells (PBMC) in sepsis. (A) UMAP plot of the cell clusters annotated by the SingleR package. (B) Bubble chart of the top five markers of each cluster. (C) Subclusters of T cells. (D) Subclusters of B cells. (E) Subclusters of monocytes. (F) Heatmaps of number of ligand-receptor pairs across cell subgroups in HC and SP. (G) The expressions of the 5 hub genes in each subclusters. *: as compared with the Control group, P <0.05; **: as compared with the Control group, P <0.01; ***: as compared with the Control group, P<0.001; ****: as compared with the Control group, P<0.0001. ns: as compared with the Control group, no significant difference. NA: Not available.