Table 4.
Differences and similarities between allergic/atopic and non-allergic/atopic patients in IgG4-RD.
| Different parameter | Similar parameter | |
|---|---|---|
| Della-Torre et al., 2020 (Italy)50 29 atopic vs 87 non-atopic |
IgG4-RD RI: 8.3 (3.2) vs 9.6 (3.0); p = 0.01 | Sex and age Number of organs involved Specific organ involvement Serum IgG4 Blood eosinophils Serum IgE Plasmablasts |
| Saeki et al., 2018 (Japan)36 22 allergic conditions vs 29 without |
Sex: Male 8 (36.4) vs 21 (72.4); p = 0.010 Age: 61.0 ± 13.2 vs 71.6 ± 8.1; p = 0.002 Specific organ involvement: Lung: 11 (50%) vs 9 (31%); p = 0.032 Upper body affected organs: 80 ± 24 vs 56 ± 32; p = 0.004 |
Number of organs involved Serum IgG4 Blood eosinophils Serum IgE IgG4-RD RI Relapse |
| Chen et al., 2016 (China)43 118 allergic vs 82 non-allergic |
Serum IgE | |
| Culver et al., 2017 (UK)4 30 allergy/atopy vs 18 without |
Serum IgE: Higher IgE ∗ p < 0.05 | |
| Culver et al., 2015 (UK)24 10 allergy/atopy vs 14 without |
Serum IgE: Higher IgE ∗ p = 0.0255 | |
| Della-Torre et al., 2014 (USA)19 22 atopic vs 48 non-atopic |
Specific organ involvement: RPF: 5 vs 29%; p = NA Serum IgG4: None Blood eosinophils: 641 cells/μL versus 365 cells/μL; p = 0.02 Serum IgE: 454 mg/dL vs153 mg/dL; p = 0.01 |
Sex and age Number of organs involved |
| Mattoo et al., 2014 (USA)20 18 atopic vs 21 non-atopic |
Specific organ involvement: salivary glands 61.1 vs 38%; p = NA lacrimal glands 22.2 vs 10%; p = ? Orbits 22.2% vs 10%; p = NA |
Sex and age Serum IgG4 |
| Mattoo et al., 2016 (USA)21 74 atopic vs 27 non-atopic |
Serum IgG4: Elevated IgG4: 79% (26/33) vs 29% (12/41) Eosinophilia: 45% (15/33) vs 17% (7/41) Elevated IgE: 61% (20/33) vs 15% (6/41) |
Sex and age |
| Grados et al., 2017 (France)22 4 atopic vs 24 non-atopic |
Blood eosinophils Serum IgE |
|
| Campochiaro et al., 2016 (Italy)23 12 atopic vs 29 non-atopic |
Blood eosinophils Serum IgE |
|
| Hirano et al., 2010 (Japan)52 7 allergic vs 35 non-allergic AIP |
Serum IgE | |
| Kamisawa et al., 2009 (Japan)33 20 allergic vs 25 non-allergic AIP |
Specific organ involvement: Less obstructive jaundice and abdominal pain; p = 0.012 and p = 0.013 Eosinophilia (>600 cells/mm3): 25% vs 0%; p = 0.013 Eosinophil count: 292.50 vs 160 cells/mm3; p = 0.048 Elevated IgE (>580 IU/mL): 80% vs 0%; p < 0.0001 Serum IgE: 793.50 IU/mL vs 176 IU/mL; p = 0.00001 |
Sex and age Serum IgG4 |
| Yamamoto et al., 2019 (Japan)55 163 sensitized (82 allergic) vs 94 non-sensitized (32 allergic) DS |
Age: 60 vs 65 years old; p < 0.005 Serum IgE: 612.66 ± 1604.96 vs 201.18 ± 285.91 IU/mL; p < 0.05 |
Sex Number of organs involved Specific organ involvement Serum IgG4 Blood eosinophils |
AIP, Auto-immune pancreatitis; DS, Dacryoadenitis and sialadenitis; IgG4-RD RI, ImmunoglobulinG4-related disease responder index; NA, not available