TABLE 1.
Response of SAP0/0 and SAP+/+ mice to TNF-α–GalN- or mTNF-α-induced lethality
| Challenge dose(s)a | Lethalityb (no. of animals killed/total no.)
|
|
|---|---|---|
| SAP+/+ | SAP0/0 (P) | |
| 0.01 μg of mTNF-α + 20 mg of GalN | 0/6 | 0/6 (NS) |
| 0.03 μg of mTNF-α + 20 mg of GalN | 4/6 | 5/6 (NS) |
| 0.1 μg of mTNF-α + 20 mg of GalN | 5/6 | 5/6 (NS) |
| 0.3 μg of mTNF-α + 20 mg of GalN | 6/6 | 6/6 (NS) |
| 2.5 μg of mTNF-α | 0/5 | 0/5 (NS) |
| 10 μg of mTNF-α | 8/10 | 5/6 (NS) |
| 20 μg of mTNF-α | 10/10 | 6/6 (NS) |
| 30 μg of mTNF-α | 10/10 | 6/6 (NS) |
a
TNF-α–GalN was given i.p., and mTNF-α was given i.v. (doses are per 20 g of body weight).
b
Lethality was scored for up to 48 h (no further deaths occurred). NS, not significantly different from SAP+/+ control mice.