TABLE 3.
hTNF-α-induced tolerization to mTNF-α-induced lethal shock in SAP+/+ and SAP0/0 mice
| Pretreatmenta | Lethalityb (no. of animals killed/total no.)
|
|
|---|---|---|
| SAP+/+ (P) | SAP0/0 (P) | |
| PBS | 6/6 | 6/6 |
| 6 μg of hTNF-α | 0/6** (0.0003) | 1/6* (0.0017) |
a
Pretreatment was given i.p. twice a day for 5 consecutive days.
b
Challenge was 25 μg of mTNF-α given i.v. at day 8 (doses are per 20 g of body weight). Lethality was scored for up to 48 h (no further deaths occurred). ∗ and ∗∗, P < 0.01 and P < 0.001, respectively, versus PBS-pretreated mice.