Table 2.
Pre-transplant demographics of adult heart-lung transplantation recipients from 2005‒2021, stratified by donor organ status.
| All patients (n = 447) | SCD heart and lung recipients (n = 178) | ECD heart only recipients (n = 70) | ECD lung only recipients (n = 134) | ECD heart and lung recipients (n = 65) | p-value | |
|---|---|---|---|---|---|---|
| Age, years | 45 [34‒54] | 43 [33‒53] | 41 [33‒49] | 47 [35‒56] | 50 [39‒54] | 0.019 |
| Female | 232 (51.9%) | 102 (57.3%) | 33 (47.1%) | 68 (50.8%) | 29 (44.6%) | 0.244 |
| Ethnicity | ‒ | ‒ | ‒ | ‒ | ‒ | ‒ |
| White | 263 (58.8%) | 102 (57.3%) | 43 (61.4%) | 83 (61.9%) | 35 (53.9%) | 0.667 |
| Black | 88 (19.7%) | 34 (19.1%) | 15 (21.4%) | 24 (17.9%) | 15 (23.1) | 0.822 |
| Hispanic | 64 (14.3%) | 27 (15.2%) | 5 (7.1%) | 18 (13.4%) | 14 (21.5%) | 0.117 |
| Body mass index, kg/m2 | 23.5 [20.8‒27.2] | 23.1 [20.1‒26.4] | 22.0 [19.5‒25.8] | 23.3 [20.9‒27.5] | 24.2 [20.9‒28.1] | 0.120 |
| Diagnosis | ‒ | ‒ | ‒ | ‒ | ‒ | ‒ |
| Primary pulmonary hypertension | 111 (24.9%) | 47 (26.4%) | 20 (29.4%) | 30 (22.4%) | 14 (21.5%) | 0.615 |
| Interstitial lung disease | 86 (19.3%) | 33 (18.5%) | 10 (14.7%) | 29 (21.6%) | 14 (21.5%) | 0.598 |
| Cardiomyopathy | 58 (13.3%) | 25 (14.0%) | 7 (10.3%) | 15 (11.2%) | 11 (16.9%) | 0.572 |
| Eisenmenger's syndrome | 45 (10.1%) | 24 (13.5%) | 7 (10.3%) | 9 (6.7%) | 5 (7.7%) | 0.245 |
| Diabetes | 65 (14.6%) | 27 (15.2%) | 3 (4.4%) | 21 (15.8%) | 14 (21.5%) | 0.040 |
| Dialysis since listing | 22 (5.0%) | 9 (5.1%) | 3 (4.7%) | 6 (4.5%) | 4 (6.2%) | 0.966 |
| Mechanical ventilation since listing | 95 (21.3%) | 35 (19.7%) | 18 (25.7%) | 29 (21.6%) | 13 (20.0%) | 0.760 |
| ECMO since listing | 76 (17.0%) | 24 (13.5%) | 13 (18.6%) | 24 (17.9%) | 15 (23.1%) | 0.327 |
| IABP since listing | 19 (4.3%) | 8 (4.5%) | 3 (4.3%) | 3 (2.2%) | 5 (7.6%) | 0.356 |
| VAD since listing | 17 (3.8%) | 5 (1.7%) | 4 (5.9%) | 8 (6.0%) | 2 (3.1%) | 0.190 |
| ICU disposition at time of transplant | 180 (40.5%) | 67 (37.6%) | 28 (41.8%) | 53 (39.6%) | 32 (49.2%) | 0.432 |
| Waiting list time, days | 75 [22‒209] | 96.5 [26‒260] | 66 [21‒165] | 87.5 [16‒186] | 68 [20‒182] | 0.363 |
| CMV positive | 269 (63.2%) | 119 (69.6%) | 32 (50.8%) | 83 (64.3%) | 35 (55.6%) | 0.032 |
| Previous heart surgery | 139 (31.2%) | 46 (25.9%) | 23 (33.8%) | 49 (36.6%) | 21 (32.3%) | 0.220 |
| Previous lung surgery | 14 (3.2%) | 3 (1.7%) | 3 (4.5%) | 5 (3.7%) | 3 (4.6%) | 0.524 |
| Cigarette use history | 133 (29.9%) | 53 (29.8%) | 14 (20.6%) | 45 (33.6%) | 21 (32.3%) | 0.278 |
| Serum creatinine > 2.0 mg/dL | 26 (6.0%) | 7 (3.9%) | 9 (12.9%) | 7 (5.2%) | 4 (6.2%) | 0.063 |
| Total bilirubin > 2.0 mg/dL | 67 (15.0%) | 22 (12.4%) | 14 (20.0%) | 22 (16.4%) | 9 (13.9%) | 0.454 |
| Cardiac output, L/min | 4.0 [3.1‒5.0] | 3.8 [3.0‒4.9] | 3.8 [3.0‒4.8] | 4.1 [3.4‒5.1] | 4.4 [3.2‒5.3] | 0.230 |
| Mean PA pressure, mmHg | 48 [34‒63] | 50 [34‒63] | 52 [38‒70] | 44.5 [34‒65] | 45 [27‒60] | 0.141 |
| Systolic PA pressure, mmHg | 74.5 [52‒96] | 79.5 [55‒96] | 77 [60‒98] | 68 [50‒99] | 69 [45‒89] | 0.239 |
| Functional deficits | ‒ | ‒ | ‒ | ‒ | ‒ | ‒ |
| Severe | 238 (54.3%) | 94 (54.0%) | 33 (50.0%) | 77 (57.9%) | 34 (52.3%) | 0.564 |
| Moderate | 145 (33.1%) | 50 (28.7%) | 25 (37.9%) | 45 (33.8%) | 25 (38.5%) | 0.386 |
| Mild to none | 55 (12.6%) | 30 (17.2%) | 8 (12.1%) | 11 (8.3%) | 6 (9.2%) | 0.206 |
| Private payor | 255 (57.1%) | 105 (59.0%) | 41 (58.6%) | 74 (55.2%) | 35 (53.9%) | 0.851 |
| Transplant era | ||||||
| 2005‒2009 | 128 (28.6%) | 66 (37.1%) | 29 (41.4%) | 26 (19.4%) | 7 (10.8%) | <0.001 |
| 2010‒2014 | 122 (27.3%) | 53 (29.8%) | 14 (20.0%) | 41 (30.6%) | 14 (21.5%) | 0.236 |
| 2015‒2021 | 197 (44.1%) | 59 (33.2%) | 27 (38.6%) | 67 (50.0%) | 44 (67.7%) | <0.001 |
All values excluding p-values are medians with IQR in brackets or frequencies with prevalence in parentheses. Each p-value is derived from Chi-Squared, Fisher's exact, or Kruskal-Wallis tests.
CMV, Cytomegalovirus; ECD, Extended criteria donor; ECMO, Extracorporeal membrane oxygenation; IABP, Intra-Aortic Balloon Pump; ICU, Intensive Care Unit; LV EF, Left Ventricular Ejection Fraction; PA, Pulmonary Artery; SCD; Standard Criteria Donor; VAD, Ventricular Assist Device.