Table 3.
Pre-transplant donor demographics of adult heart-lung transplantation recipients from 2005‒2021, stratified by donor organ status.
| All patients | SCD heart and lung recipients | ECD heart only recipients | ECD lung only recipients | ECD heart and lung recipients | p-value | |
|---|---|---|---|---|---|---|
| Female | 228 (51.0%) | 107 (60.1%) | 26 (37.1%) | 69 (51.5%) | 26 (40.0%) | 0.002 |
| Age, years | 31 [21‒43] | 29 [20‒43] | 24 [19‒33] | 35.5 [23‒44] | 31 [23‒42] | 0.002 |
| Body mass index, m/kg2 | 24.4 [21.7‒27.6] | 23.6 [21.4‒26.8] | 24.2 [20.9‒28.5] | 24.7 [22.0‒27.5] | 25.6 [23.3‒28.3] | 0.015 |
| Ethnicity | ‒ | ‒ | ‒ | ‒ | ‒ | |
| White | 252 (56.4%) | 100 (56.2%) | 43 (61.4%) | 70 (52.2%) | 39 (60.0%) | 0.571 |
| Black | 68 (15.2%) | 23 (12.9%) | 15 (21.4%) | 22 (16.4%) | 8 (12.3%) | 0.334 |
| Hispanic | 98 (21.9%) | 47 (26.4%) | 10 (14.3%) | 28 (20.9%) | 13 (20.0%) | 0.195 |
| Hypertension | 73 (16.5%) | 30 (17.1%) | 9 (12.9%) | 22 (16.7%) | 12 (18.5%) | 0.827 |
| Diabetes | 20 (4.5%) | 10 (5.7%) | 1 (1.4%) | 9 (6.8%) | 0 (0.0%) | 0.080 |
| Heavy alcohol use | 47 (10.7%) | 18 (10.2%) | 10 (14.3%) | 9 (7.0%) | 10 (15.6%) | 0.215 |
| On inotropes at procurement | 217 (48.8%) | 102 (57.3%) | 30 (43.5%) | 59 (44.0%) | 26 (40.6%) | 0.031 |
| LV EF | 60% [55‒65%] | 61% [56‒65%] | 60% [55‒65%] | 60.5% [55‒65%] | 60% [55‒65%] | 0.570 |
| P/F ratio | 450 [369‒509] | 461 [390‒517] | 471 [393‒520] | 437 [344‒488] | 423 [334‒497] | 0.001 |
| Cold ischemic time, hours | 3.8 [3.1‒4.4] | 3.8 [3.0‒4.4] | 3.4 [2.9‒4.3] | 3.9 [3.2‒4.4] | 3.8 [3.1‒4.2] | 0.539 |
| Donor/recipient weight ratio | 1.1 [0.9‒1.3] | 1.1 [0.9‒1.2] | 1.2 [0.8‒1.5] | 1.0 [0.9‒1.2] | 1.0 [0.8‒1.4] | 0.198 |
| Donor/recipient predicted total lung capacity ratio | 1.0 [0.9‒1.1] | 1.0 [0.9‒1.1] | 1.0 [0.9‒1.2] | 1.0 [0.9‒1.1] | 1.0 [0.9‒1.1] | 0.230 |
| HLA mismatches | 5 [4‒5] | 5 [4‒5] | 5 [4‒6] | 5 [4‒5] | 5 [4‒5] | 0.947 |
All values excluding p-values are medians with IQR in brackets or frequencies with prevalence in parentheses. Each p-value is derived from Chi-Squared, Fisher's exact, or Kruskal-Wallis tests.
ECD, Extended Criteria Donor; HLA, Human Leukocyte Antigen; LV EF, Left Ventricular Ejection Fraction; P/F ratio, Ratio of arterial oxygen partial pressure to fraction of inspired oxygen; SCD, Standard Criteria Donor.