Table 4.
Pre-transplant extended donor criteria of adult heart-lung transplantations from 2005‒2021, stratified by donor organ status.
| All patients | SCD heart and lung recipients | ECD heart only recipients | ECD lung only recipients | ECD heart and lung recipients | p-value | |
|---|---|---|---|---|---|---|
| Age ≥ 55 years | 19 (4.3%) | 2 (1.1%) | 2 (2.9%) | 5 (3.7%) | 10 (15.4%) | <0.001 |
| Cold ischemic time > 6-hours | 30 (6.7%) | 9 (5.1%) | 15 (21.4%) | 3 (2.2%) | 3 (4.6%) | <0.001 |
| Donor/recipient weight ratio 〈0.80 or〉≥ 1.30 | 156 (34.9%) | 36 (20.2%) | 50 (71.4%) | 30 (22.4%) | 40 (61.5%) | <0.001 |
| Hepatitis C positivity | 9 (2.0%) | 1 (0.6%) | 1 (1.4%) | 0 (0.0%) | 7 (10.8%) | <0.001 |
| Drug use history | 199 (45.0%) | 51 (29.0%) | 50 (72.5%) | 48 (36.4%) | 50 (76.9%) | <0.001 |
| Serum creatinine > 2.0 mg/dL | 55 (12.3%) | 6 (3.4%) | 21 (30.0%) | 6 (4.5%) | 22 (33.9%) | <0.001 |
| LV EF < 50% | 6 (1.3%) | 0 (0.0%) | 2 (2.9%) | 1 (0.8%) | 3 (4.6%) | 0.026 |
| Donation after circulatory death | 27 (6.1%) | 5 (2.8%) | 11 (15.9%) | 0 (0.0%) | 11 (16.9%) | <0.001 |
| Infiltrate on chest radiograph | 220 (49.8%) | 39 (22.4%) | 13 (18.8%) | 113 (84.3%) | 55 (84.6%) | <0.001 |
| P/F ratio < 300 | 36 (8.1%) | 3 (1.7%) | 2 (2.9%) | 20 (14.9%) | 11 (16.9%) | <0.001 |
| Purulent secretions on bronchoscopy | 72 (16.4%) | 9 (5.1%) | 3 (4.5%) | 43 (32.1%) | 17 (27.0%) | <0.001 |
| Cigarette use history (> 20 pack-years) | 45 (10.3%) | 6 (3.4%) | 9 (13.0%) | 21 (16.3%) | 9 (14.1%) | 0.001 |
All values excluding p-values are medians with IQR in brackets or frequencies with prevalence in parentheses. Each p-value is derived from chi squared, Fisher's exact, or Kruskal-Wallis tests.
CMV, Cytomegalovirus; ECD, Extended Criteria Donor; LV EF, Left Ventricular Ejection Fraction; P/F ratio, Ratio of arterial oxygen partial pressure to Fraction of inspired oxygen; SCD, Standard Criteria Donor.