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. 2023 Jan 18;78(5):780–789. doi: 10.1093/gerona/glad018

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© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Citrate is associated with DC leukocyte telomere loss and a shift in systemic energy metabolism. (A) Linear regression analysis showing a statistically significant association between age-adjusted telomere reduction (LAATL) and plasma citrate (upper panel) and malate (lower panel) in DC patients (n = 19). (B) Non-normalized data from 4 DC families showing that DC patients with shorter telomeres than their older relatives carrying the same mutation show a trend for increased plasma citrate (upper panel) and malate (lower panel). The values over the bars indicate the level of age-adjusted telomere reduction. DC = dyskeratosis congenita; LAATL = leukocyte age-associated telomere loss.