Table 4.
Percentage of Variance in Cognitive Domain Scores Explained by Genetic Risk Factors in LASI-DAD
| General Cognitive Function | Orientation | Executive Function | Language/Fluency | Memory | Visuospatial Function | |
|---|---|---|---|---|---|---|
| Age + sex + 10 PCsa | 27.66% | 26.70% | 24.66% | 29.24% | 22.13% | 9.97% |
| APOEb | 0.21% | 0.28% | 0.10% | 0.49% | 0.16% | 0.03% |
| PRSAD_Lambertb | 0.36% | 0.08% | 0.30% | 0.35% | 0.29% | 0.66% |
| PRSAD_Jansenb | 0.42% | 0.05% | 0.38% | 0.56% | 0.50% | 0.28% |
| PRSAD_Kunkleb | 0.75% | 0.21% | 0.61% | 0.51% | 0.89% | 1.11% |
| PRSAD_Wightmanb | 0.31% | 0.06% | 0.29% | 0.21% | 0.23% | 0.53% |
| PRSAD_Bellenguezb | 0.33% | 0.04% | 0.37% | 0.09% | 0.43% | 0.51% |
| APOE + 5 AD PRSsb | 1.04% | 0.51% | 0.82% | 1.25% | 1.39% | 1.20% |
| PRSGenCogb | 0.39% | 0.77% | 0.23% | 0.07% | 0.19% | 0.20% |
| APOE + 5AD PRSs + PRSGenCogb | 1.53% | 1.36% | 1.11% | 1.37% | 1.66% | 1.46% |
| APOE + 5AD PRSs + PRSGenCogc | 0.65% | 0.75% | 0.45% | 0.83% | 1.01% | 0.86% |
Notes: AD = Alzheimer’s disease; APOE = apolipoprotein E; LASI-DAD = Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India; PRS = polygenetic risk score; PRSAD_Lambert = Alzheimer’s disease polygenetic risk score calculated using the identified risk SNPs from Lambert et al. (3); PRSAD_Jansen = Alzheimer’s disease polygenetic risk score calculated using the identified risk SNPs from Jansen et al. (4); PRSAD_Kunkle = Alzheimer’s disease polygenetic risk score calculated using the identified risk SNPs from Kunkle et al. (5); PRSAD_Wightman = Alzheimer’s disease polygenetic risk score calculated using the identified risk SNPs from Wightman et al. (6); PRSAD_Bellenguez = Alzheimer’s disease PRS calculated using the identified risk SNPs from Bellenguez et al. (7); PRSGenCog = general cognitive function polygenetic risk score calculated using the identified risk SNPs from Davies et al. (9). All PRSs are standardized to an N(0,1) distribution.
aChange in R2 when the variable(s) were added to a null model.
bChange in R2 when the variable(s) were added to the following model: cognitive domain score ~ age + sex + 10 PCs.
cChange in R2 when the variable(s) were added to the following model: cognitive domain score ~ age + sex + 10 PCs + education.