Table 1.
Differentially expressed genes of whole gene expression transcriptomic profiling of gas plasma-treated human urothelial cancer tissues with at least a twofold increase or decrease. The table is sorted for up and downregulation and fold-changes (FC) in expression.
| Gene | FDR | regulation | log2(FC) | Gene | FDR | regulation | log2(FC) |
|---|---|---|---|---|---|---|---|
| TMEM200C | 2.83 | down | −5.36 | GNLY | 1.34 | up | 2.41 |
| FGFBP1 | 2.15 | down | −4.13 | GBA | 1.37 | up | 2.41 |
| KLHDC7B | 1.60 | down | −3.89 | RNF225 | 1.33 | up | 2.41 |
| TBX1 | 1.92 | down | −3.67 | APBB3 | 1.35 | up | 2.42 |
| ANXA8L1 | 1.66 | down | −3.44 | SFTPA1 | 1.36 | up | 2.43 |
| BTBD16 | 1.84 | down | −3.36 | PIP5K1A | 1.38 | up | 2.45 |
| SFN | 1.60 | down | −3.34 | LAIR1 | 1.36 | up | 2.45 |
| PKP3 | 1.62 | down | −3.09 | CAP2 | 1.38 | up | 2.45 |
| SPRR2D | 1.49 | down | −3.03 | KLHL6 | 1.34 | up | 2.45 |
| ANGPTL7 | 1.42 | down | −3.00 | NPAS3 | 1.34 | up | 2.48 |
| KLHDC7B | 1.47 | down | −2.92 | LRRD1 | 1.36 | up | 2.48 |
| PADI1 | 1.38 | down | −2.81 | CTRC | 1.34 | up | 2.49 |
| GJB4 | 1.47 | down | −2.81 | ALPI | 1.32 | up | 2.49 |
| LY6D | 1.40 | down | −2.80 | OR5H1 | 1.40 | up | 2.50 |
| TNS4 | 1.42 | down | −2.76 | PCDHGA3 | 1.38 | up | 2.50 |
| SPRR2A | 1.47 | down | −2.75 | MBLAC1 | 1.37 | up | 2.50 |
| TUT4 | 1.47 | down | −2.75 | PDILT | 1.33 | up | 2.51 |
| AQP3 | 1.51 | down | −2.74 | CXCL13 | 1.43 | up | 2.51 |
| KRT14 | 1.37 | down | −2.70 | SELL | 1.30 | up | 2.51 |
| CLDN1 | 1.44 | down | −2.63 | PRDM16 | 1.36 | up | 2.52 |
| TENM2 | 1.44 | down | −2.62 | TMEM241 | 1.43 | up | 2.52 |
| EDN2 | 1.34 | down | −2.59 | PPCDC | 1.43 | up | 2.53 |
| IL20RB | 1.44 | down | −2.58 | RASD2 | 1.40 | up | 2.53 |
| PAGE2 | 1.43 | down | −2.53 | RPL32 | 1.39 | up | 2.53 |
| FGFR3 | 1.36 | down | −2.49 | SLC30A2 | 1.33 | up | 2.54 |
| SPRR1B | 1.38 | down | −2.45 | SNORA60 | 1.36 | up | 2.56 |
| TMPRSS4 | 1.31 | down | −2.27 | SRGAP1 | 1.38 | up | 2.57 |
| SLC22A7 | 1.30 | up | 2.24 | PRDM13 | 1.40 | up | 2.57 |
| NPBWR1 | 1.32 | up | 2.27 | PCARE | 1.43 | up | 2.57 |
| CCT8L2 | 1.33 | up | 2.32 | EHMT1 | 1.44 | up | 2.58 |
| SGPP2 | 1.32 | up | 2.33 | TSGA13 | 1.31 | up | 2.59 |
| REP15 | 1.33 | up | 2.33 | GCLM | 1.30 | up | 2.61 |
| CBLIF | 1.32 | up | 2.34 | NR4A1 | 1.46 | up | 2.62 |
| NANOS3 | 1.33 | up | 2.34 | ANKRD63 | 1.39 | up | 2.63 |
| CHST13 | 1.34 | up | 2.34 | FCRLA | 1.46 | up | 2.63 |
| ARG1 | 1.34 | up | 2.35 | SMIM10L2A | 1.46 | up | 2.63 |
| OLIG3 | 1.30 | up | 2.35 | RPS6KA1 | 1.46 | up | 2.63 |
| COL9A1 | 1.36 | up | 2.36 | TAS2R13 | 1.34 | up | 2.64 |
| TMEM178B | 1.35 | up | 2.38 | LTF | 1.36 | up | 2.64 |
| SLC4A10 | 1.30 | up | 2.39 | OPA3 | 1.37 | up | 2.65 |
| JAG2 | 1.36 | up | 2.39 | FAM107A | 1.44 | up | 2.66 |
| HMX3 | 1.37 | up | 2.40 | OR10P1 | 1.33 | up | 2.66 |
| GPR160 | 1.33 | up | 2.40 | VSIG10L2 | 1.34 | up | 2.66 |
| Gene | FDR | regulation | log2(FC) | Gene | FDR | regulation | log2(FC) |
| XAGE-4 | 1.38 | up | 2.66 | DPYS | 1.32 | up | 2.93 |
| ODF3L2 | 1.43 | up | 2.67 | LRRC2 | 1.57 | up | 2.95 |
| CHST12 | 1.37 | up | 2.67 | EOMES | 1.40 | up | 2.95 |
| SLC26A1 | 1.43 | up | 2.67 | SCARNA3 | 1.66 | up | 2.96 |
| OR4S1 | 1.38 | up | 2.68 | NANOS2 | 1.62 | up | 2.97 |
| IGLL5 | 1.44 | up | 2.69 | RSPH1 | 1.40 | up | 2.97 |
| BMP3 | 1.50 | up | 2.69 | SNORA59B | 1.32 | up | 2.97 |
| CD19 | 1.45 | up | 2.70 | COL20A1 | 1.54 | up | 2.98 |
| SPOCK2 | 1.47 | up | 2.70 | ELFN1 | 1.62 | up | 2.99 |
| OR1J1 | 1.41 | up | 2.70 | PPP1R11 | 1.66 | up | 3.00 |
| CTRC | 1.46 | up | 2.71 | RIT2 | 1.59 | up | 3.02 |
| SV2C | 1.47 | up | 2.71 | IGLL1 | 1.50 | up | 3.03 |
| CST6 | 1.34 | up | 2.71 | PLEKHG4B | 1.52 | up | 3.03 |
| DET1 | 1.43 | up | 2.71 | FAT2 | 1.51 | up | 3.03 |
| LCE3B | 1.43 | up | 2.71 | DYNC2LI1 | 1.57 | up | 3.05 |
| COMMD7 | 1.46 | up | 2.72 | SLC25A47 | 1.61 | up | 3.06 |
| AIF1L | 1.44 | up | 2.72 | GOLGA7B | 1.44 | up | 3.06 |
| MUC5AC | 1.43 | up | 2.73 | BTN2A1 | 1.66 | up | 3.09 |
| SPATA9 | 1.33 | up | 2.74 | CPB1 | 1.36 | up | 3.11 |
| TAF1L | 1.44 | up | 2.75 | CNP | 1.59 | up | 3.12 |
| CACNA1C | 1.52 | up | 2.76 | PRPF40B | 1.60 | up | 3.12 |
| OVOS2 | 1.45 | up | 2.76 | RNF24 | 1.54 | up | 3.13 |
| ACP4 | 1.43 | up | 2.77 | STK16 | 1.66 | up | 3.14 |
| TBC1D14 | 1.50 | up | 2.78 | ATP13A2 | 1.74 | up | 3.19 |
| FAM47A | 1.51 | up | 2.78 | TCL1A | 1.49 | up | 3.22 |
| SPRY4 | 1.44 | up | 2.78 | CYP4Z1 | 1.57 | up | 3.28 |
| DDO | 1.50 | up | 2.78 | MMP28 | 1.76 | up | 3.31 |
| DNPEP | 1.44 | up | 2.78 | SLC27A1 | 1.83 | up | 3.31 |
| PCDH19 | 1.45 | up | 2.79 | UBIAD1 | 1.68 | up | 3.34 |
| HSPB8 | 1.50 | up | 2.79 | SLC22A11 | 1.71 | up | 3.36 |
| SLC17A4 | 1.54 | up | 2.79 | SPATA1 | 1.83 | up | 3.39 |
| RNU105C | 1.35 | up | 2.79 | RETREG2 | 1.67 | up | 3.40 |
| XRCC3 | 1.45 | up | 2.82 | CCDC66 | 1.70 | up | 3.40 |
| DNAH2 | 1.54 | up | 2.83 | ANKRD30A | 1.66 | up | 3.44 |
| CHMP6 | 1.44 | up | 2.86 | HELZ2 | 1.71 | up | 3.48 |
| NHLH2 | 1.44 | up | 2.87 | ALKAL2 | 1.46 | up | 3.49 |
| CDH24 | 1.58 | up | 2.87 | ZG16 | 1.82 | up | 3.49 |
| NT5DC4 | 1.51 | up | 2.87 | MTR | 1.92 | up | 3.50 |
| ANKRD20A2 | 1.51 | up | 2.89 | SYCE2 | 1.66 | up | 3.53 |
| TMEM40 | 1.61 | up | 2.89 | IL36B | 1.86 | up | 3.55 |
| MRAP | 1.42 | up | 2.89 | SAA1 | 1.57 | up | 3.55 |
| MEGF11 | 1.54 | up | 2.91 | SAA2 | 1.37 | up | 3.56 |
| CHRD | 1.58 | up | 2.93 | SERPINB13 | 1.89 | up | 3.58 |
| XAGE-4 | 1.38 | up | 2.66 | DPYS | 1.32 | up | 2.93 |
| ODF3L2 | 1.43 | up | 2.67 | LRRC2 | 1.57 | up | 2.95 |
| Gene | FDR | regulation | log2(FC) | Gene | FDR | regulation | log2(FC) |
|---|---|---|---|---|---|---|---|
| GRAMD1B | 1.85 | up | 3.64 | RBFOX1 | 1.64 | up | 4.22 |
| EDA | 1.89 | up | 3.65 | MED15 | 2.37 | up | 4.24 |
| TSHB | 1.92 | up | 3.68 | AIFm2 | 1.91 | up | 4.35 |
| USP30 | 1.47 | up | 3.71 | CR2 | 2.15 | up | 4.36 |
| GPR78 | 1.75 | up | 3.74 | PIH1D2 | 2.01 | up | 4.37 |
| SNORA71B | 2.00 | up | 3.76 | TAS2R19 | 1.66 | up | 4.46 |
| TEX37 | 2.00 | up | 3.83 | TMCC2 | 1.67 | up | 4.56 |
| PDXK | 1.95 | up | 3.85 | ISLR2 | 2.47 | up | 4.64 |
| FDCSP | 1.88 | up | 3.88 | GLYAT | 2.66 | up | 4.92 |
| SULT6B1 | 1.76 | up | 3.91 | LDB1 | 2.66 | up | 5.01 |
| CACHD1 | 1.98 | up | 3.91 | PCDH11X | 2.66 | up | 5.20 |
| MIR100HG | 2.00 | up | 3.93 | GHSR | 2.75 | up | 5.24 |
| L3MBTL2 | 1.76 | up | 3.93 | EXOC1L | 2.66 | up | 5.48 |
| SSBP3 | 2.12 | up | 3.99 | LY6G5C | 2.66 | up | 5.49 |
| OTOG | 1.84 | up | 4.06 | ST18 | 2.40 | up | 5.82 |
| MIR100HG | 2.20 | up | 4.06 | OR6Y1 | 3.15 | up | 6.23 |
| APBA1 | 2.26 | up | 4.06 | TSPAN32 | 3.15 | up | 6.44 |
| FOXR1 | 1.98 | up | 4.10 | MRTFB | 3.01 | up | 6.86 |