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. Author manuscript; available in PMC: 2023 May 11.
Published in final edited form as: Sci Transl Med. 2021 Jun 2;13(596):eabg4535. doi: 10.1126/scitranslmed.abg4535

Fig. 6: MAbs targeting the lateral patch and RBS are potently protective in vivo.

Fig. 6:

(A to D) Epitope mAb cocktails (5 mAbs per cocktail) were administered prophylactically by intraperitoneal injection, and mice were infected 2 hours later with 10 LD50 of A/Netherlands/602/2009 H1N1 virus intranasally. Weight loss (A) and survival (B) were measured for mice treated with 1 mg/kg of mAb cocktails. Weight loss (C) and survival (D) were measured for mice treated with 0.2 mg/kg of mAb cocktails (E) 2D class averages of a RBS clone (SFV009 2G01; red) and lateral patch clone (045–09 2B05; blue) binding the same HA. Data in A and C are the mean ± standard deviation (n=10 mice per group), and data from A-D are pooled from two independent experiments. Dashed lines in A and C represent the humane end point of 25% weight loss.