Fig. 16.

Schematic illustration of metal ions and collagen-based dynamic hydrogel loaded with KGN promoting cartilage regeneration by enhanced mitochondrial functions. (A) Gelatin is mercaptoized with Traut's reagent to form mercapto gelatin (SH-Gel). (B) Self-healing ability is endowed by introducing gold chlorate, followed by mixing with cyclodextrin-encapsulated KGN. (C) The “cutting and healing” remoldable network structure was achieved through an “Au–S″a dynamic bond. (D) In vivo injection of hydrogel facilitates cartilage repair following injury through refinement of mitochondrial polarization and redox balance. Reproduced with permission [86]. Copyright 2022, Elsevier B.V. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)