Table 1. Prioritized Mutations and Pathogenicity Predicted by Five In Silico Tools.

protein change	phD-SNP	PMut	PROVEAN	SIFT	PolyPhen2
R434P	disease	disease	deleterious	deleterious	probably damaging
H533N	disease	disease	deleterious	deleterious	benign
P613L	disease	disease	deleterious	deleterious	probably damaging
T701M	disease	disease	deleterious	deleterious	probably damaging
A704T	disease	disease	deleterious	deleterious	probably damaging
S720C	neutral	disease	deleterious	deleterious	probably damaging
R725W	disease	disease	deleterious	deleterious	probably damaging
R725Q	disease	disease	deleterious	deleterious	possibly damaging
R726Q	disease	disease	deleterious	deleterious	benign
S732F	neutral	neutral	deleterious	deleterious	benign