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Crosstalk between macrophages and fibroblasts. A The role of Gata6+ pericardial macrophages (GPCMs) remains controversial. B Macrophages secrete cytokines (such as IL-10, IGF-1, FGFs, PDGFs, angiotensinogen II) to promote fibrosis. C Macrophages secrete exosomes enriched with circUbe3a, HIF-1, or mir-155 to inhibit fibrosis. D Macrophages may be transformed into fibroblast-like cells
