Table 1.
| Markers | Type | Location | Species | Monocyte | RTM | M1 | M2 |
|---|---|---|---|---|---|---|---|
| CD45 | Receptor | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | ＋/＋ | ＋/＋ |
| CD11b | Receptor | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | ＋/＋ | ＋/＋ |
| CD11c | Receptor | Cell membranes | Human/Mouse | ＋/- | -/- | ＋/- | -/- |
| CD68 | Receptor | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | ＋/＋ | ＋/＋ |
| CD80 | Receptor | Cell membranes | Human/Mouse | -/- | low/low | ＋/＋ | ＋/＋ |
| CD86 | Receptor | Cell membranes | Human/Mouse | ＋/＋ | -/- | ＋/＋ | ＋/＋ |
| CD206 | Receptor、 Lectin | Cell membranes | Human/Mouse | ＋/＋ | ＋/＋ | -/- | ＋/＋ |
| iNOS | Enzyme | Cytoplasm | Human/Mouse | -/- | -/- | ＋/＋ | -/- |
| Arg1 | Enzyme | Cytoplasm | Human/Mouse | -/- | ＋/＋ | -/- | ＋/＋ |
| CCR2 | Receptor | Cell membranes | Human/Mouse | ±/± | -/- | high/＋ | low/± |
| CX3CR1 | Receptor | Cell membranes | Human/Mouse | -/± | -/- | low/± | high/＋ |
| IL-6 | Cytokine | Secreted | Human/Mouse | -/- | -/- | ＋/＋ | -/- |
| IL-10 | Cytokine | Secreted | Human/Mouse | -/- | ＋/＋ | -/- | ＋/＋ |
| TNF-α | Cytokine | Secreted | Human/Mouse | -/- | -/- | ＋/＋ | -/- |
| CD14 | Receptor | Cell membranes | Human | ＋ | ＋ | high | ＋ |
| CD16 | Receptor | Cell membranes、Secreted | Human | ± | ＋ | - | high |
| HLA-DR | Multi-subunit complex、Receptor | Cell membranes | Human | ＋ | ＋ | ＋ | ＋ |
| F4/80 | Receptor | Cell membranes | Mouse | ＋ | ＋ | ＋ | ＋ |
| Ly-6C | Receptor | Cell membranes | Mouse | high/low | low | high | low |
| MHC-II | Multi-subunit complex、Receptor | Cell membranes | Mouse | ＋ | ＋ | ＋ | ＋ |
| Fizz1 | Other | Secreted | Mouse | - | - | - | ＋ |
| Ym1 | Lectin | Nucleus、Secreted | Mouse | - | - | - | ＋ |
RTM tissue-resident macrophage