Table 2.
Factors of advance fibrosis progression in NAFLD patients in univariate and multivariate analysis
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| AUC | CI | P-value | Odds ratio | 95%CI | P-value | |
| Age | 0.63 | 1.03–9.23 | 0.003 | 5.6 | 1.12–30.1 | 0.0356 |
| Gender (F) | 0.61 | 0.36–1.04 | 0.0707 | 0.72 | 0.35–1.43 | 0.3472 |
| ALT | 0.4146 | 0.4146 | ||||
| AST | 0.656 | 0.58–0.72 | 0.0061 | 4.05 | 0.61–27.7 | 0.1451 |
| Platelet count | 0.6132 | 0.5399–0.6866 | 0.0199 | 1.74 | 0.22–13.2 | 0.5931 |
| Ferritin | 0.56 | 0.4783–0.6389 | 0.0161 | 2.51 | 0.2–34.5 | 0.4756 |
| Total Cholesterol | 0.767 | 0.767 | ||||
| Alubumin | 0.6448 | 0.5709–0.7170 | 0.0002 | 0.11 | 0.01–0.7 | 0.023 |
| P-III-P | 0.6567 | 0.5858–0.7285 | < 0.0001 | |||
| Type 4 collagen7S | 0.7699 | 0.7008–0.8342 | < 0.0001 | |||
| Hyaluronic acid | 0.7588 | 0.6927–0.8236 | < 0.0001 | |||
| WFA+M2BP | 0.6879 | 0.6121–0.7622 | < 0.0001 | |||
| sCD163 | 0.7262 | 0.6551–0.7911 | < 0.0001 | 43.9 | 4.86–481 | 0.0006 |
CI; confidence interval, ALT, alanine aminotransferase; AST, aspartate aminotransferase; P-III-P, procollagen-III-peptide, WFA+M2BP, Wisteria floribunda agglutinin Mac-2 binding protein; sCD163, soluble CD163.