Table 3.
Patients with NAFLD who underwent repeated liver biopsies
| Clinical and histological characteristics | ||||
|---|---|---|---|---|
| n = 119 | ||||
| Age, years | 50.2 ± 14.2 | |||
| Male/Female | 64/55 | |||
| BMI (kg/m2) | 27.9 ± 3.6 | |||
| Fibrosis, 0/1/2/3/4 | 12/42/27/37/1 | |||
| Grade, 0/1/2/3 | 9/45/42/23 | |||
| Steatosis, 0/1/2/3 | 1/37/51/30 | |||
| Biomarkers in NAFLD and NASH | ||||
| First time | Second time | P-value | ||
| ALT (IU/l) | 91 ± 55 | 45 ± 34 | < 0.0001 | |
| AST (IU/l) | 54.2 ± 27.2 | 36.6 ± 19.7 | < 0.0001 | |
| γ-GTP (IU/l) | 77.4 ± 54.4 | 55.7 ± 57 | < 0.0001 | |
| T- Bilirubin (mg/dl) | 0.7 ± 0.3 | 0.8 ± 0.3 | 0.1124 | |
| Total Cholesterol (ng/dl) | 207 ± 35.7 | 189 ± 35.8 | 0.0012 | |
| Cholinesterase (IU/l) | 255 ± 98 | 330 ± 91.7 | < 0.0001 | |
| Platelet count (104/ug) | 21.3 ± 6.1 | 20.6 ± 6.5 | 0.4892 | |
| HOMA-I R | 3.8 ± 2.8 | 3.2 ± 2.0 | 0.1738 | |
| Iron (ug/dl) | 122 ± 37.9 | 116 ± 37.9 | 0.2847 | |
| Ferritin (ng/dl) | 219 ± 183 | 138 ± 140 | 0.0001 | |
| Leptin (ng/dl) | 11.4 ± 6.5 | 12.0 ± 7.7 | 0.8855 | |
| Adiponectin (ug/ml) | 5.9 ± 2.5 | 6.6 ± 3.5 | 0.4023 | |
| High-sensitivity CRP (mg/dl) | 178 ± 153 | 174 ± 298 | 0.0012 | |
| P-III-P (U/ml) | 0.7 ± 0.1 | 0.6 ± 0.1 | < 0.0001 | |
| Type 4 collagen 7 S (ng/ml) | 4.1 ± 0.8 | 3.9 ± 0.9 | 0.1841 | |
| Hyaluronic acid (ng/ml) | 45.3 ± 48.2 | 54.1 ± 50 | 0.0925 | |
| TIMP-1 (ng/ml) | 180 ± 42.2 | 156 ± 55.2 | 0.0234 | |
| CK18 (micro/l) | 705 ± 520 | 566 ± 475 | 0.0152 | |
| M2BPGi (C.O.I) | 1.05 ± 0.5 | 0.91 ± 0.49 | 0.0297 | |
| sCD163 (ng/ml) | 742 ± 298 | 658 ± 290 | 0.0122 | |
BMI, body mass index; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; sCD163, soluble CD163