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. 2023 May 11;14:78. doi: 10.1186/s40104-023-00876-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The colocalization of eQTLs and GWAS loci. a Manhattan plot showing the colocalization results (H4 > 0.8) between eQTL and GWAS signals. The x-axis is the P-value of lead eQTLs (points) across traits (colors) in muscle. b Manhattan plot showing SMR P-value between GWAS signals and eQTLs in different traits (colors) and tissues (point shape). c An example of GWAS–eQTL colocalization for GARMD1C in adipose. The colors of variants are based on their LD with the most significant variant. d An example of GWAS–eQTL colocalization for TIGAR in muscle