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. 2023 May 10;20:112. doi: 10.1186/s12974-023-02791-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — MCC950 restored CUMS-induced activation of Aβ metabolic pathway. A The expression of target protein was detected by Western Blotting. B Both MCC950 and fluoxetine could inhibit CUMS induced up-regulation of APP. C Both MCC950 and fluoxetine could relieve the increased expression of BACE1 induced by CUMS. D CUMS induced down-regulation of IDE, which could be improved by MCC950 and fluoxetine intervention. The data were shown by mean and standard error (Mean ± SEM). (n = 3 for each group, *P < 0.05, **P < 0.01)