Table 6.

Unadjusted and adjusted Hazard Ratios for all-cause mortality in partner participants

	Unadjusted Cox Model			Adjusted Cox Model1			Multivariable Cox Model2
	HR	95% CI3	p-value4	aHR	95% CI3	p-value4	aHR	95% CI3	p-value4
Age	1.04	0.97, 1.11	0.264	1.04	0.97, 1.12	0.211	1.04	0.97, 1.11	0.230
Gender			0.801			0.409			0.522
Female	REF			REF			REF
Male	1.20	0.34, 7.58		1.80	0.50,11.49		1.58	0.44,10.13
Study site			0.173			0.130			0.061
Indonesia	REF			REF			REF
Ukraine	1.78	0.57, 7.81		1.57	0.49, 7.02		2.02	0.63, 8.97
Vietnam	0.66	0.15, 3.35		0.52	0.11, 2.70		0.56	0.12, 2.90
Study arm			0.026			0.023			0.029
SOC	REF			REF			REF
Intervention	0.17	0.01, 0.84		0.17	0.01, 0.82		0.18	0.01, 0.86
Alcohol use in the past 3 months			0.225			0.393
Non Hazardous alcohol use	REF			REF
Hazardous alcohol use	1.76	0.70, 4.36		1.51	0.58, 3.94
Injecting opioids in the past 3 months5			0.071			0.103
No	REF			REF
Yes	3.64	0.48,466.7		3.06	0.37,399.1
Injecting stimulants in the past 3 months			0.790			0.239
No	REF			REF
Yes	0.85	0.20, 2.55		0.48	0.11, 1.58
Injecting other drugs in the past 3 months			0.294			0.933
No	REF			REF
Yes	1.71	0.60, 4.34		0.95	0.30, 3.00
No injecting drug use in the past 3 months5			0.090			0.149
No	REF			REF
Yes	0.32	0.00, 2.48		0.41	0.00, 3.73
Injecting polydrug use in the past 3 months			0.320			0.635
No	REF			REF
Yes	1.60	0.62, 3.95		0.75	0.24, 2.61
# of days of injecting drugs use in the past month	1.03	0.99, 1.08	0.134	1.03	0.98, 1.08	0.277
Non-injecting opioids use in the past 3 months			0.754			0.989
No	REF			REF
Yes	0.74	0.04, 3.57		0.99	0.05, 5.18
Non-injecting stimulants use in the past 3 months			0.700			0.753
No	REF			REF
Yes	0.82	0.26, 2.15		0.84	0.25, 2.37
Non-injecting other drug use in the past 3 months			0.857			0.884
No	REF			REF
Yes	1.09	0.44, 2.81		0.93	0.37, 2.49
No non-injecting drug use in the past 3 months			0.965			0.799
No	REF			REF
Yes	1.02	0.36, 2.59		1.14	0.39, 2.98
Non-injecting polydrug use in the past 3 months			0.822			0.916
No	REF			REF
Yes	0.88	0.25, 2.43		0.94	0.25, 2.76
OAT status			0.046			0.036			0.081
ever used	REF			REF			REF
OAT naïve	2.68	1.02, 8.32		2.81	1.06, 8.78		2.38	0.90, 7.40

¹ Age, gender, site, arm was adjusted for in the Adjusted Cox Models

² Those significant in the adjusted cox models were selected in this model with conservative cutoff point of 0.1. adjusting for age, gender, site, arm, only those with p-value < 0.1 will be left in the final model

³ Profile likelihood 95% confidence interval

⁴ Logrank type3 p-value

⁵ Firth's method with Breslow for ties was used when there was a zero event count. Elsewhere Efron's method was used for ties