TABLE 1.
Demographics and neuropsychological characteristics of HCs, SCD, and aMCI three groups.
HCs (n = 42) | SCD (n = 43) | aMCI (n = 40) | p | |
---|---|---|---|---|
Age (years) | 63.82 (7.35) | 63.63 (7.10) | 64.65 (7.99) | 0.673 a |
Gender (M/F) | 16/26 | 10/33 | 18/22 | 0.104 b |
Education level (years) | 12.36 (2.41) | 11.85 (3.26) | 11.89 (3.08) | 0.679 a |
MMSE | 29.00 (28.00, 30.00) | 28.00 (27.00, 29.00) | 27.50 (26.00, 29.00) | 0.055 c |
MoCA | 26.00 (25.00, 28.00) | 25.00 (24.00, 27.00) | 24.00 (22.00, 25.00) d ,*, e ,**, f ,*** | 0.000 c |
MDRS‐2 | 142.00 (140.75, 144.00) | 141.00 (139.00, 143.00) | 138.00 (135.25, 141.00) d ,*, e ,**, f ,*** | 0.001 c |
Composite Z scores of each cognitive domain | ||||
Episodic memory | 0.28 (0.59) | 0.21 (0.62) | −0.52 (0.55) e ,***, f ,*** | 0.000 a |
Executive function | 0.16 (0.53) | 0.27 (0.52) | −0.46 (0.56) e ,***, f ,*** | 0.000 a |
Information processing speed | 0.12 (0.75) | 0.17 (0.70) | −0.31 (0.71) e ,**, f ,* | 0.006 a |
Visuospatial function | 0.30 (−0.18, 0.64) | 0.15 (−0.37, 0.64) | 0.01 (−0.50, 0.64) | 0.141 c |
Note: Numbers are given as means (standard deviation, SD) or median (interquartile range, IQR).
Abbreviations: aMCI, amnestic mild cognitive impairment; HCs, healthy controls; MDRS‐2, Mattis Dementia Rating Scale‐2; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment test; SCD, subjective cognitive decline.
One‐way ANOVA.
Chi‐square test.
Kruskal‐Wallis H‐test.
Post hoc analyses showed a significant group difference between HCs and SCD.
Post hoc analyses showed a significant group difference between SCD and aMCI.
Post hoc analyses showed a significant group difference between HCs and aMCI.
*p < 0.05, **p < 0.01, ***p < 0.001.