TABLE 1.
Classification of FGF ligands and their corresponding receptors.
| Function manner | FGF subfamily | FGFs | FGFRs | Co‐receptors |
|---|---|---|---|---|
| Paracrine FGFs | FGF1 | FGF1 (aFGF) | All FGFRs | HSPGs |
| FGF2 (bFGF) | FGFR1b, FGFR1c, FGFR2c, FGFR3c, FGF4 | |||
| FGF4 | FGF4 | FGFR1c, FGFR2c, FGFR3c, FGF4 | ||
| FGF5 | FGFR1c, FGFR2c | |||
| FGF6 | FGFR1c, FGFR2c, FGFR3c, FGF4 | |||
| FGF7 | FGF3 | FGFR1b, FGFR2b | ||
| FGF7 (KGF) | FGFR1b, FGFR2b | |||
| FGF10 | FGFR1b, FGFR2b | |||
| FGF22 | FGFR1b, FGFR2b | |||
| FGF8 | FGF8 | FGFR1c, FGF2c, FGFR3b, FGFR3c, FGFR4 | ||
| FGF17 | FGFR1c, FGF2c, FGFR3b, FGFR3c, FGFR4 | |||
| FGF18 | FGFR1c, FGF2c, FGFR3b, FGFR3c, FGFR4 | |||
| FGF9 | FGF9 | FGFR1c, FGF2c, FGFR3b, FGFR3c, FGFR4 | ||
| FGF16 | FGFR1c, FGF2c, FGFR3b, FGFR3c, FGFR4 | |||
| FGF20 | FGFR1c, FGF2c, FGFR3b, FGFR3c, FGFR4 | |||
| Endocrine FGFs | FGF19 | FGF15/19 | FGFR1c, FGF2c, FGFR3c, FGFR4 | β‐Klotho |
| FGF21 | FGFR1c, FGFR3c | |||
| FGF23 | FGFR1c, FGFR3c, FGFR4 | α‐Klotho | ||
| Intracellular FGFs | FHFs | FGF11 | ||
| FGF12 | ||||
| FGF13 | ||||
| FGF14 |
Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; HSPGs, heparin sulfate (HS)/proteoglycans.