Table 2.

Overview of study outcomes

	Indicator	Timeline
Primary outcome	Mortality	90 days
Secondary outcomes
Logistical	Days free of ICU	30 days
	Days free of ventilation	30 days
	Days free of RRTa	30 days
	Days free of hospital	30 days
Physiological	APACHE IIb scoresup to	30 daysc
	SOFAd scoresup to	30 daysc
	Pa02/Fi02e ratiosup to	30 daysc
	ARDSf scoresup to	30 daysc
Safety	enterocutaneous fistula	30 days
	ACSg and/or severe IAHh	30 days
	Intra-abdominal abscess	30 days
	Need for reoperation	30 days

^aRRT = Renal Replacement Therapy

^bAcute Physiology and Chronic Health Evaluation Score

^cMeasured daily using the worst value of that day

^dSOFA = Sequential organ Failure Assessment

^ePa0₂/Fi0₂ = Partial pressure of oxygen over inspired fraction of oxygen

^fARDS = Acute Respiratory Distress Syndrome

^gACS = Abdominal Compartment Syndrome

^hIAH = Intrabdominal Hypertension