TABLE 1.
Baseline Characteristics of the HRQoL-analysis Study Population (N=105)
| Study population (N=105) | Active surveillance group* (n=71) | Active treatment group† (n=30) | |
|---|---|---|---|
| Median age at time of diagnosis (y) | 37 (32–47) | 37 (33–49) | 36 (31–46) |
| Sex, n (%) | |||
| Male | 21 (20) | 14 (19) | 7 (23) |
| Female | 84 (80) | 61 (81) | 23 (77) |
| Tumor localization, n (%) | |||
| Abdominal wall | 37 (35) | 30 (40) | 7 (23) |
| Head and neck | 8 (8) | 3 (4) | 5 (17) |
| Upper extremity | 7 (7) | 4 (5) | 3 (10) |
| Trunk and back | 25 (24) | 19 (26) | 6 (20) |
| Breast | 10 (9) | 7 (9) | 3 (10) |
| Lower extremity | 18 (17) | 12 (16) | 6 (20) |
| Recurrent disease, n (%) | |||
| Yes | 6 (6) | 4 (5) | 2 (7) |
| Median tumor size (cm) | 4.1 (3.0–6.6) | 3.8 (3.0–6.0) | 5.0 (3.8–7.6) |
| Symptoms at time of inclusion‡, n (%) | |||
| Yes | 68 (65) | 49 (65) | 19 (63) |
| Mean HRQoL scores (n=95)§ | |||
| Functioning scales¶ | |||
| Global health | 72.6 (19.4) | 72.0 (19.8) | 74.1 (18.5) |
| Physical functioning | 88.9 (14.8) | 88.2 (15.8) | 90.6 (12.3) |
| Role functioning | 81.4 (23.0) | 82.1 (23.6) | 79.6 (21.8) |
| Emotional functioning | 72.1 (25.5) | 71.9 (24.9) | 72.5 (27.6) |
| Cognitive functioning | 86.5 (19.4) | 86.3 (20.1) | 87.0 (18.1) |
| Social functioning | 85.6 (22.3) | 85.6 (21.9) | 85.8 (23.9) |
| Symptom scales/items|| | |||
| Fatigue | 23.5 (23.4) | 23.2 (23.7) | 24.3 (23.1) |
| Nausea and vomiting | 4.4 (11.2) | 4.9 (11.9) | 3.1 (9.3) |
| Pain | 22.8 (22.9) | 21.1 (22.6) | 27.2 (23.6) |
| Dyspnea | 7.4 (18.3) | 7.4 (17.1) | 7.4 (21.4) |
| Insomnia | 20.7 (27.1) | 18.1 (26.7) | 27.2 (27.8) |
| Appetite loss | 5.6 (14.3) | 4.9 (13.2) | 7.4 (16.9) |
| Constipation | 7.4 (17.7) | 6.0 (14.1) | 11.1 (24.5) |
| Diarrhea | 11.9 (39.8) | 12.1 (44.8) | 11.1 (24.5) |
| Financial difficulties | 7.8 (20.4) | 9.5 (22.3) | 3.7 (14.1) |
Values are presented as median (IQR), mean (±SD) or n (%).
*
Patients who continued active surveillance from baseline to 24-month follow-up.
†
Patients who started an active treatment during 24-month follow-up.
‡
Sensory symptoms, motoric symptoms, cosmetic complaints, pain, cramps.
§
Mean HRQoL scores were calculated based on the available questionnaires at baseline.
¶
Higher scores indicate better functioning.
||
Higher scores indicate a higher level of symptomatology / problems.
HRQoL indicates health-related quality of life; IQR, interquartile range.