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. 2023 Feb 13;68(5):485–497. doi: 10.1165/rcmb.2022-0321MA

Figure 4.

Figure 4.

Cutaneous exposure to lewisite/DPCA causes airway remodeling in mice. (A) Representative lung histology with Picrosirius staining showing collagen deposition around airways at Weeks 10 and 20. Scale bars, 100 μm. (B) Hydroxyproline content at 10 weeks. (C) Hydroxyproline content at 20 weeks. (D) Representative lung histology with α-SMA (alpha smooth muscle actin) staining at Weeks 10 and 20. Scale bars, 100 μm. (E) Immunoblot analysis in whole lung tissue lysates for MUC5AC (mucin 5 AC). β-actin expression was used as loading control. (F) Densitometry of MUC5AC expression. Each dot represents an individual mouse. *P < 0.05, **P < 0.01, and ***P < 0.001 using one-way ANOVA followed by Tukey’s post hoc analysis.