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. 2023 May 9;220(8):e20220727. doi: 10.1084/jem.20220727

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© 2023 Lin et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 2. — Transcriptomic profiling reveals TLR3-driven IFN-stimulated gene expression influenced by ZNRF1 in BMDMs. (A) Heatmap showing the changes of type I IFN–related gene expression in Znrf1^+/+ and Znrf1^−/− BMDMs after 4 h treatment with poly(I:C) (30 μg/ml). (B) Volcano plot of the changes of differential gene expression in Znrf1^−/− BMDMs after 4 h treatment with 30 μg/ml poly(I:C) against wild-type BMDMs. The x axis indicates the logarithm of P values to the base 2 of the fold change, and the y axis reveals the negative logarithm of that to the base 10. Red dots denote transcripts related to type I IFN production in response to poly(I:C). (C) GO analysis of the differential expressed genes from B.