Table 6.

Random effects meta-analyses results between PD and PSP subjects.

Region	Number of studies	Subjects		SMD	[95% CI]	Overall effect		Heterogeneity
		PD	HCs			Z	P	I 2 [%]	P
Frontal lobe	4	32	48	−0.55	[−1.06, −0.04]	−2.124	0.034	13.4	0.325
Prefrontal lobe	2	21	74	0.06	[−0.49, 0.61]	0.204	0.838	0	0.814
Parietal lobe	5	47	62	−0.30	[−0.84, 0.23]	−1.113	0.266	42.6	0.138
Occipital lobe	3	33	41	−0.05	[−0.58, 0.48]	−0.192	0.848	20.2	0.286
Temporal lobe	3	33	49	−0.32	[−0.78, 0.13]	−1.394	0.163	0	0.508
Lat.temporal lobe	2	16	22	−0.65	[−1.33, 0.02]	−1.891	0.059	0	0.706
Striatum	3	24	53	−1.28	[−2.21, −0.34]	−2.659	0.008	64.9	0.058
Caudate nucleus	4	57	73	0.30	[−0.17, 0.77]	1.257	0.209	36.1	0.195
Putamen	6	71	140	−0.86	[−1.33, −0.40]	−3.636	0	46.0	0.099
Globus pallidus	6	71	140	−1.77	[−2.53, −1.02]	−4.614	0	73.3	0.002
Thalamus	4	39	55	−1.44	[−2.42, −0.47]	−2.904	0.004	74.3	0.009
Subthalamic nucleus	5	65	142	−2.05	[−2.77, −1.32]	−5.532	0	68.8	0.012
Midbrain	3	24	48	−2.16	[−3.22, −1.10]	−4.007	0	63.6	0.064
Substantia nigra	5	63	133	−1.12	[−1.59, −0.65]	−4.640	0	40.8	0.149
Red nucleus	2	36	53	−0.90	[−1.68, −0.12]	−2.256	0.024	61.1	0.109
Pons	2	32	46	−0.67	[−1.99, 0.65]	−0.996	0.319	79.7	0.026
Dentate nucleus	5	63	133	−1.00	[−1.58, −0.42]	−3.358	0.001	62.2	0.032
Cerebellar deep white matter	2	14	28	−1.77	[−3.13, −0.41]	−2.557	0.011	67.8	0.078
Post.cingulate	2	23	29	−0.92	[−2.80, 0.96]	−0.962	0.336	88.7	0.003
Entorhinal	2	28	54	−0.24	[−0.66, 0.18]	−1.123	0.261	0	0.952
Inf.temporal lobe	2	28	54	−0.35	[−0.77, 0.08]	−1.609	0.108	0	0.500

PD, Parkinson's disease; PSP, progressive supranuclear palsy; SMD, Standardized mean difference; CI, confidence interval. The bold values indicate the value of P < 0.05.