Table 7.

Subgroup analysis based on the type of tau tracer used for studies involving PSP and PD subjects.

Region	Tracer	Number of studies	Subjects		SMD	[95% CI]	Overall effect		Heterogeneity
			PD	PSP			Z	P	I 2 [%]	P
Frontal lobe	1st generation	3	22	28	−0.62	[−1.40, 0.16]	−1.561	0.119	40.1	0.188
	2nd generation	1	10	20	−0.44	[−1.21, 0.33]	−1.118	0.264	N/A	N/A
Parietal lobe	1st generation	4	37	42	−0.31	[−1.04, 0.41]	−0.839	0.401	56.8	0.074
	2nd generation	1	10	20	−0.32	[−1.08, 0.45]	−0.809	0.418	N/A	N/A
Occipital lobe	1st generation	2	23	21	0.03	[−0.83, 0.90]	0.077	0.939	48.3	0.164
	2nd generation	1	10	20	−0.27	[−1.03, 0.49]	−0.693	0.488	N/A	N/A
Temporal lobe	1st generation	2	23	29	−0.27	[−0.90, 0.35]	−0.858	0.391	18.6	0.268
	2nd generation	1	10	20	−0.43	[−1.20, 0.33]	−1.107	0.268	N/A	N/A
Striatum	1st generation	2	14	28	−1.69	[−2.71, −0.67]	−3.238	0.001	45.5	0.175
	2nd generation	1	10	20	−0.60	[−1.37, 0.18]	−1.507	0.132	N/A	N/A
Caudate nucleus	1st generation	3	47	53	0.39	[−0.21, 0.98]	1.276	0.202	45.6	0.159
	2nd generation	1	10	20	0.00	[−0.76, 0.76]	0	1.000	N/A	N/A
Putamen	1st generation	4	55	60	−0.70	[−1.40, 0.00]	−1.954	0.051	62.7	0.045
	2nd generation	2	16	80	−1.09	[−1.68, −0.50]	−3.643	0	0	0.419
Globus pallidus	1st generation	4	55	60	−1.98	[−3.18, −0.78]	−3.241	0.001	81.6	0.001
	2nd generation	2	16	80	−1.41	[−2.02, −0.80]	−4.520	0	0	0.640
Thalamus	1st generation	3	29	35	−1.71	[−3.14, −0.28]	−2.348	0.019	80.5	0.006
	2nd generation	1	10	20	−0.85	[−1.64, −0.06]	−2.099	0.036	N/A	N/A
Subthalamic nucleus	1st generation	3	49	62	−2.58	[−3.71, −1.45]	−4.484	0	74.6	0.019
	2nd generation	2	16	80	−1.37	[−1.98, −0.76]	−4.384	0	0	0.378
Midbrain	1st generation	2	14	28	−2.68	[−3.56, −1.79]	−5.920	0	0	0.325
	2nd generation	1	10	20	−1.35	[−2.19, −0.52]	−3.167	0.002	N/A	N/A
Substantia nigra	1st generation	3	47	53	−0.94	[−1.68, −0.20]	−2.497	0.013	59.3	0.086
	2nd generation	2	16	80	−1.41	[−2.02, −0.80]	−4.566	0	0	0.783
Pons	1st generation	2	32	46	−0.67	[−1.99, 0.65]	−0.996	0.319	79.7	0.026
	2nd generation	0	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Dentate nucleus	1st generation	3	47	53	−0.82	[−1.62, −0.02]	−2.000	0.046	67.0	0.048
	2nd generation	2	16	80	−1.28	[−2.51, −0.05]	−2.043	0.041	76.4	0.040
Cerebellar deep white matter	1st generation	2	14	28	−1.77	[−3.13, −0.41]	−2.557	0.011	67.8	0.078
Post.cingulate	1st generation	2	23	29	−0.92	[−2.80, 0.96]	−0.962	0.336	88.7	0.003
	2nd generation	0	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Entorhinal	1st generation	2	28	54	−0.24	[−0.66, 0.18]	−1.123	0.261	0	0.952
	2nd generation	0	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Inf.temporal lobe	1st generation	2	28	54	−0.35	[−0.77, 0.08]	−1.609	0.108	0	0.500
	2nd generation	0	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

PD, Parkinson's disease; PSP, progressive supranuclear palsy; SMD, Standardized mean difference; CI, confidence interval; N/A, Not applicable. The bold values indicate the value of P < 0.05.