Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 27;14:1145441. doi: 10.3389/fimmu.2023.1145441

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Tang, Kong, Wang, Zou, Sun, Liu, Zhang, Jin, Mao, Zhu, Wang, Meng and You

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of Dec and Aza on the exhaustion and phenotypic differentiation of CD44v6 CAR-T. (A, B) TIM3, LAG3 and PD-1 expression levels of non-transduced T (NT) and CD44v6 CAR-T cells treated with Dec (0.05, 0.1 μM) (A) and Aza (0.5, 1 μM) (B) for 6 days (n=4). (C) CD69 expression level of NT and CD44v6 CAR-T cells treated with Dec (0.05, 0.1 μM) (left) and Aza (0.5, 1 μM) (right) for 6 days (n=4) (D, E) CCR7 and CD45RA surface staining was performed on NT and CD44v6 CAR-T cells (n=5) treated with Dec (0.05, 0.1 μM) and Aza (0.5, 1 μM) for 6 days, representative flow cytometry is shown in D, the changes of phenotype of CD44v6 CAR-T cells are indicated in (E) MFI, mean fluorescence intensity; Teff, effector T cells; Tcm, central memory T cells; Tem, effector memory T cells. Data are depicted as the mean ± SD. *p<.05; **p<.01; ***p<.001; ****p<.0001; ns, not significant.