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. 2023 Apr 27;14:1145441. doi: 10.3389/fimmu.2023.1145441

Figure 5.

Figure 5

Dec and Aza treatment promotes the apoptosis and CD44v6 expression on AML cells. (A, B) Apoptosis of MV4-11, SKM-1, SKM-1-DNMT3A-SC2 and SKM-1-DNMT3A-SC3 cells (n=3) after treatment with different concentrations of Dec (A) and Aza (B) for 3 days. (C, D) CD44v6 MFI fold change of MV4-11, SKM-1, SKM-1-DNMT3A-SC2 and SKM-1-DNMT3A-SC3 cells (n=4) after treatment with different concentrations of Dec (C) and Aza (D) for 3 days. CD44v6 MFI fold change is the ratio of CD44v6 MFI of Dec and Aza treated CD44v6 CAR-T divided by the CD44v6 MFI of untreated CD44v6 CAR-T. SKM-1-DNMT3A-SC2 and SKM-1-DNMT3A-SC3: two clones of DNMT3A-R882H mutant of SKM-1 cells. MFI, mean fluorescence intensity. Data are depicted as the mean ± SD. *p<.05; **p<.01; ***p<.001; ****p<.0001; ns, not significant.