Table 5.

Potential effects of Citrus aurantifolia swings in treatment of CHF.

Study	Therapeutic component	Dose/active constitute/extract	Type of study	Major findings/mechanism
Souza et al[128]	Inotropic	aqueous extract of C aurantifolia	In vitro rat aorta	Negative inotropic and chronotropic effects on the heart contractile activity
Akhtar[129]	Antihypertensive	methanol extract of C aurantifolia 0.75mg orally	In vivo rats	Significantly reduced systolic blood pressure, mean blood pressure, diastolic blood pressure, heart rate and body weight in both normotensive and hypertensive experimental models
Souza et al[128]	Antihypertensive	aqueous extract of C aurantifolia	In vivo rabbit	Dose-dependent and significant decrease in blood pressure of adrenalin-evoked hypertension
Hashemipour et al[131]	Antihypertensive	C aurantifolia peels	Triple-masked randomized controlled trial in adolescents with excess weight	SBP was significantly decreased in intervention group in a before-after analysis
Siti et al[132]	Antihypertensive	Citrus leaf extract	In vivo palm oil induced-hypertension Sprague Dawley rats	Reduce blood pressure, thromboxane and angiotensin-1 converting enzyme
Souza et al[128]	Vasodilator	aqueous extract of C aurantifolia	In vivo rabbit	Dose dependent relaxation of contractions produced by adrenalin

CHF = chronic heart failure, SBP = systolic blood pressure.