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. 2023 Apr 27;13:1165790. doi: 10.3389/fcimb.2023.1165790

Figure 4.

Figure 4

Association of intratumoral microbiome abundance with patient survival and tumor immune infiltrates. (A) Spearman’s correlation between Shannon index and the relative abundance of Lactobacillus and Leptotrichia(p-value by Spearman’s rank correlation, N = 98). (B) Genus level correlation network maps mainly reflected the genus (relative abundance top 100)-relatedness in tumors, correlation threshold (Rs ≥ 0.70 by Spearman’s rank correlation). Different colors represent different phyla, and relative abundances at genus level are directly proportional to the sizes of the circles. (C) Kaplan–Meier analysis with the log-rank test for OS probability based on Lactobacillus and Leptotrichia in 98 ESCC patients. (D) Spearman’s correlation between Shannon index or Lactobacillus and the percent of tumor immune cells in 98 samples (p-value by Spearman’s rank correlation). * p < 0.05. ** p < 0.01. *** p < 0.001. OS, overall survival; ESCC, esophageal squamous cell carcinoma.