Skip to main content
. 2023 May 11;21(5):e3002100. doi: 10.1371/journal.pbio.3002100

Fig 2. C. difficile response to metronidazole or vancomycin is modified in specific pairwise communities.

Fig 2

(A) Heatmaps of MIC of monocultures in the presence of metronidazole (MTZ) or vancomycin (VAN). Species indicated by 2-letter species code (Fig 1B). (B, C) Line plots of species absolute abundance at 48 h as a function of antibiotic concentration for C. difficile in monoculture or C. difficile in pairwise communities. Each x-axis is semi-log scale. The values on the y-axis are calculated OD600 (OD600 multiplied by relative abundance from 16S rRNA gene sequencing). Data points indicate individual biological replicates. Lines indicate the average of n = 1 to n = 8 biological replicates. Vertical gray line and bold number indicate MIC of C. difficile in each condition. Color indicates species (Fig 1B). The data underlying all panels in this figure can be found in DOI: 10.5281/zenodo.7626486. MIC, minimum inhibitory concentration.