Figure 4.

Estimated kinetic parameters for different EGFR expression cancer-type groups (High: A431, Moderate:MDA-MB-231, Low: BT-474, Control: SW620). (a) $k_{\mathit{1}}$ - rate constant governing the imaging agent transfer from staining/rinsing solution to interstitial space. (b) $k_{\mathit{2}}$ - rate constant governing the imaging agent transfer from interstitial space out to staining/rinsing solution. (c) $k_{\mathit{3}}$ - rate constant governing the targeted agent from interstitial space associate with its specific receptor. (d) $k_{\mathit{4}}$ - rate constant governing the separation of the bound imaging agent back into the interstitial space.