Figure 1: Neutrophils exert PMN-MDSC function following activation.

A) Activation of neutrophils by a number of stimuli (e.g., fMLF or TNF-α) can induce T cell suppressor function dependent on cell-cell contact by adhesion, ROS formation, degranulation and trogocytosis. B) The processes of adhesion, ROS production and degranulation have been proven essential for strongly suppressing T cells an in vitro model resulting in reduced T cell proliferation and irreparable T cell damage (right panel). Data are adapted from Aarts et al.⁶⁵