Exposure–response functions: percentage increase in case–fatality risk (%IR), and 95% confidence intervals (95% CI), per increasing levels of air pollutants, from natural spline models. Italy, 20 February 2020–15 June 2021 ( COVID-19 cases, deaths). Relevant data in Excel Table S2. Y axes of the top graphs display percentage increases of risk, x axes of the top graphs report air pollutants concentrations. Bottom graphs show histograms of air pollutants’ distributions. Results from the main model, adjusted for interaction terms between month, province, age, sex, and ventiles of the generalized propensity score.