Table 1.
Baseline characteristics of HIV patients before receiving ART by types of ART regimen.
| Variables | Normal range | All patients (n = 633) | NNRTIs (n = 422) | INSTIs (n = 211) | p Value |
|---|---|---|---|---|---|
| Age, years, median [IQR] | NA | 31 [25–44] | 31 [24–44] | 33 [26–45] | 0.059 |
| Gender, Female, n (%) | NA | 31 (4.9) | 24 (5.7) | 7 (3.3) | 0.193 |
| Weight, (kg), median [IQR] | NA | 64 [59–71] | 64 [60–70] | 65 [57–72] | 0.725 |
| BMI, (kg/m2), median [IQR] | 18.5–24.9 | 21.5 [19.7–23.4] | 21.5 [19.6–23.6] | 21.6 [20.0–23.3] | 0.919 |
| Underweight, n (%) | <18.5 | 45 (7.1) | 25 (5.9) | 20 (9.5) | |
| Normal, n (%) | 18.5–24.9 | 273 (43.1) | 164 (38.9) | 109 (51.7) | |
| Overweight, n (%) | 25–29.9 | 53 (8.4) | 32 (7.6) | 21 (10.0) | |
| Obese, n (%) | >30 | 8 (1.3) | 5 (1.2) | 3 (1.4) | |
| Lack of BMI data/unknown, n (%) | NA | 254 (40.1) | 196 (46.4) | 58 (27.5) | |
| Drinking habit, n (%) | NA | 105 (16.6) | 71 (16.8) | 34 (16.1) | 0.821 |
| Smoking habit, n (%) | NA | 116 (18.3) | 73 (17.3) | 43 (20.4) | 0.383 |
| Hypertension, n (%) | NA | 31 (4.9) | 18 (4.3) | 13 (6.2) | 0.297 |
| Laboratory findings | All patients (n = 546) | NNRTIs (n = 377) | INSTIs (n = 169) | ||
| FPG, mmol/L, median [IQR] | 3.9–6.1 | 5.13 [4.78–5.55] | 5.09 [4.79–5.54] | 5.21 [4.76–5.57] | 0.649 |
| IFG, n (%) | 5.6–6.9 | 103 (18.9) | 67 (17.8) | 36 (21.3) | 0.539 |
| Diabetes, n (%) | ≥7.0 | 17 (3.1) | 14 (3.7) | 3 (1.8) | 0.228 |
| TC, mmol/L, median [IQR] | <5.18 | 3.88 [3.43–4.47] | 3.86 [3.44–4.45] | 3.90 [3.42–4.55] | 0.744 |
| Normal, n (%) | <200 mg/dl; <5.18 mmol/l | 502 (91.9) | 348 (92.3) | 154 (91.1) | |
| Borderline-high, n (%) | 200-239 mg/dl; 5.18–6.21 mmol/l | 37 (6.8) | 23 (6.1) | 14 (8.3) | 0.467 |
| High, n (%) | ≥240 mg/dl; ≥6.21 mmol/l | 7 (1.3) | 6 (1.6) | 1 (0.6) | |
| TG, mmol/L, median [IQR] | <1.70 | 1.14 [0.85–1.61] | 1.13 [0.84–1.57] | 1.20 [0.87–1.72] | 0.152 |
| Normal, n (%) | <150 mg/dl; <1.70 mmol/l | 427 (78.2) | 301 (79.8) | 126 (74.6) | |
| Borderline-high, n (%) | 150-199 mg/dl;1.70–2.26 mmol/l | 66 (12.1) | 44 (11.7) | 22 (13.0) | 0.293 |
| High, n (%) | ≥200 mg/dl; ≥2.26 mmol/l | 53 (9.7) | 32 (8.5) | 21 (12.4) | |
| HDL-C, mmol/L, median [IQR] | >1.04 | 0.98 [0.84–1.12] | 0.98 [0.85–1.12] | 0.97 [0.80–1.12] | 0.443 |
| Low, n (%) | <40 mg/dl; <1.04 mmol/l | 338 (61.9) | 232 (61.5) | 106 (62.7) | |
| Borderline-high, n (%) | 40-59 mg/dl; 1.04–1.55 mmol/l | 195 (35.7) | 136 (36.1) | 59 (34.9) | 0.967 |
| High, n (%) | ≥60 mg/dl; ≥1.55 mmol/l | 13 (2.4) | 9 (2.4) | 4(2.4) | |
| LDL-C, mmol/L, median [IQR] | <3.37 | 2.44 [1.97–2.85] | 2.45 [2.01–2.83] | 2.42 [1.89–2.88] | 0.439 |
| Normal, n (%) | <130 mg/dl; <3.37 mmol/l | 490 (89.7) | 340 (90.2) | 150 (88.8) | |
| Borderline-high, n (%) | 130-159 mg/dl; 3.37–4.14 mmol/l | 43 (7.9) | 27 (7.2) | 16 (9.5) | 0.588 |
| High, n (%) | ≥160 mg/dl; ≥4.14 mmol/l | 13 (2.4) | 10 (2.7) | 3 (1.8) | |
| Lp(a), mg/dL, median [IQR] | <30 | 7.59 [4.63–15.01] | 7.48 [4.64–15.75] | 7.98 [4.44–13.09] | 0.581 |
| Normal, n (%) | <30 mg/dl | 492 (90.1) | 337 (89.4) | 155 (91.7) | |
| Abnormal, n (%) | ≥30 mg/dl | 54 (9.9) | 40 (10.6) | 14 (8.3) | 0.400 |
| CD4 count, cells/mm3, median [IQR] | 550–1,440 | 274 ± 153 | 284 ± 147 | 257 ± 163 | 0.410 |
| Absolute T lymphocyte count, cells/mm3, median [IQR] | 955–2,860 | 1,232 [817–1701] | 1,228 [879–1764] | 1,247 [718–1,454] | 0.246 |
NA = not available. p values < 0.05 are written in italics.
Values shown are mean ± SD, median (interquartile range [IQR]) or n (%). p values were calculated by Chi-squared test, Fisher’s exact test, t test, or Mann–Whitney U test, as appropriate.
HIV, human immune deficiency virus; ART, antiretroviral therapy, n number; IQR, Inter Quartile Range; SD, standard deviation, % percentage; NNRTIs, non-nucleoside reverse transcriptase inhibitor; INSTIs, integrase strand transfer inhibitors; BMI, body mass index; FPG, fasting plasma glucose; IFG, impaired fasting glucose; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; Lipoprotein(a), Lp(a).