Table 2.
Comparison of blood lipid levels between baseline data with different follow-up periods by types of ART regimen.
| Baseline | At 6 months | p-value | At 12 months | P-value | At 18 months | p-value | At 24 months | p-value | At 30 months | p-value | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A. NNRTIs Group, mean ± SD | |||||||||||
| TC, mmol/L | 4.00 ± 0.83 | 4.12 ± 0.84 | 0.063 | 4.20 ± 0.91 | 0.004 | 4.26 ± 1.01 | 0.001 | 4.42 ± 1.02 | <0.001 | 4.28 ± 1.07 | 0.006 |
| TG, mmol/L | 1.32 ± 0.76 | 1.46 ± 1.02 | 0.039 | 1.47 ± 0.91 | 0.029 | 1.48 ± 1.35 | 0.074 | 1.69 ± 1.47 | <0.001 | 1.58 ± 1.66 | 0.026 |
| HDL-C, mmol/L | 1.00 ± 0.25 | 1.08 ± 0.24 | <0.001 | 1.11 ± 0.25 | <0.001 | 1.11 ± 0.27 | <0.001 | 1.13 ± 0.25 | <0.001 | 1.11 ± 0.25 | <0.001 |
| LDL-C, mmol/L | 2.50 ± 0.74 | 2.43 ± 0.66 | 0.216 | 2.49 ± 0.72 | 0.859 | 2.55 ± 0.81 | 0.463 | 2.61 ± 0.73 | 0.122 | 2.51 ± 0.70 | 0.850 |
| Lp(a), mg/dL | 10.95 ± 9.40 | 9.75 ± 8.93 | 0.098 | 9.37 ± 8.48 | 0.032 | 10.23 ± 9.87 | 0.396 | 10.36 ± 8.44 | 0.579 | 9.73 ± 9.56 | 0.252 |
| TC/HDL-C | 4.19 ± 1.14 | 3.96 ± 1.03 | 0.005 | 3.90 ± 0.93 | 0.001 | 4.01 ± 1.46 | 0.013 | 4.03 ± 1.03 | 0.150 | 3.99 ± 1.29 | 0.127 |
| TG/HDL-C | 1.49 ± 1.16 | 1.50 ± 1.32 | 0.883 | 1.45 ± 1.14 | 0.694 | 1.51 ± 1.74 | 0.856 | 1.64 ± 1.56 | 0.251 | 1.58 ± 2.06 | 0.541 |
| LDL-C/ HDL-C | 2.61 ± 0.91 | 2.33 ± 0.72 | <0.001 | 2.31 ± 0.70 | <0.001 | 2.40 ± 0.99 | 0.009 | 2.38 ± 0.67 | 0.006 | 2.34 ± 0.72 | 0.006 |
| B. INSTIs Group, mean ± SD | |||||||||||
| Baseline | At 6 months | P-value | At 12 months | P-value | At 18 months | P-value | At 24 months | P-value | At 30 months | P-value | |
| TC, mmol/L | 4.00 ± 0.88 | 4.31 ± 0.87 | 0.001 | 4.40 ± 0.87 | <0.001 | 4.48 ± 1.01 | <0.001 | 4.42 ± 0.96 | 0.003 | 4.59 ± 1.05 | 0.001 |
| TG, mmol/L | 1.53 ± 1.24 | 1.83 ± 1.72 | 0.067 | 1.79 ± 1.45 | 0.087 | 1.86 ± 1.73 | 0.015 | 1.81 ± 1.54 | 0.165 | 1.93 ± 1.26 | 0.038 |
| HDL-C, mmol/L | 0.97 ± 0.25 | 1.04 ± 0.22 | 0.015 | 1.07 ± 0.24 | 0.001 | 1.05 ± 0.24 | 0.017 | 1.09 ± 0.25 | 0.002 | 1.08 ± 0.21 | 0.025 |
| LDL-C, mmol/L | 2.42 ± 0.79 | 2.53 ± 0.70 | 0.187 | 2.61 ± 0.68 | 0.029 | 2.74 ± 0.72 | 0.002 | 2.66 ± 0.76 | 0.043 | 2.83 ± 0.98 | 0.009 |
| Lp(a), mg/dL | 10.24 ± 8.36 | 9.45 ± 7.92 | 0.381 | 8.83 ± 7.76 | 0.143 | 8.74 ± 8.10 | 0.178 | 8.02 ± 7.79 | 0.106 | 7.16 ± 6.74 | 0.055 |
| TC/HDL-C | 4.31 ± 1.25 | 4.33 ± 1.26 | 0.921 | 4.26 ± 1.11 | 0.703 | 4.49 ± 1.74 | 0.345 | 4.19 ± 1.16 | 0.526 | 4.42 ± 1.30 | 0.643 |
| TG/HDL-C | 1.79 ± 1.78 | 2.04 ± 2.76 | 0.318 | 1.88 ± 1.90 | 0.646 | 2.07 ± 2.83 | 0.332 | 1.93 ± 2.22 | 0.623 | 2.06 ± 1.82 | 0.413 |
| LDL-C/ HDL-C | 2.60 ± 1.00 | 2.51 ± 0.80 | 0.336 | 2.51 ± 0.73 | 0.357 | 2.70 ± 0.84 | 0.417 | 2.50 ± 0.75 | 0.501 | 2.70 ± 1.00 | 0.605 |
| C. All patients, mean ± SD | |||||||||||
| Baseline | At 6 months | P-value | At 12 months | P-value | At 18 months | P-value | At 24 months | P-value | At 30 months | P-value | |
| TC, mmol/L | 4.00 ± 0.85 | 4.19 ± 0.85 | <0.001 | 4.27 ± 0.90 | <0.001 | 4.32 ± 1.01 | <0.001 | 4.42 ± 1.00 | <0.001 | 4.35 ± 1.07 | 0.001 |
| TG, mmol/L | 1.39 ± 0.94 | 1.59 ± 1.13 | 0.004 | 1.57 ± 1.11 | 0.006 | 1.59 ± 1.48 | 0.015 | 1.73 ± 1.48 | <0.001 | 1.66 ± 1.58 | 0.009 |
| HDL-C, mmol/L | 0.99 ± 0.25 | 1.06 ± 0.24 | <0.001 | 1.10 ± 0.25 | <0.001 | 1.09 ± 0.26 | <0.001 | 1.12 ± 0.25 | <0.001 | 1.10 ± 0.24 | <0.001 |
| LDL-C, mmol/L | 2.47 ± 0.76 | 2.46 ± 0.68 | 0.846 | 2.53 ± 0.71 | 0.269 | 2.60 ± 0.79 | 0.020 | 2.63 ± 0.74 | 0.015 | 2.59 ± 0.78 | 0.107 |
| Lp(a), mg/dL | 10.73 ± 9.08 | 9.64 ± 8.58 | 0.058 | 9.19 ± 8.25 | 0.009 | 9.79 ± 9.40 | 0.171 | 9.65 ± 9.75 | 0.026 | 9.12 ± 9.02 | 0.071 |
| TC/HDL-C | 4.23 ± 1.18 | 4.09 ± 1.13 | 0.049 | 4.02 ± 1.01 | 0.003 | 4.15 ± 1.56 | 0.423 | 4.08 ± 1.07 | 0.114 | 4.10 ± 1.30 | 0.249 |
| TG/HDL-C | 1.58 ± 1.39 | 1.69 ± 1.56 | 0.301 | 1.59 ± 1.44 | 0.921 | 1.67 ± 2.13 | 0.460 | 1.72 ± 1.83 | 0.275 | 1.70 ± 2.01 | 0.421 |
| LDL-C/ HDL-C | 2.61 ± 0.94 | 2.40 ± 0.75 | <0.001 | 2.38 ± 0.72 | <0.001 | 2.49 ± 0.96 | 0.079 | 2.42 ± 0.70 | 0.009 | 2.43 ± 0.81 | 0.041 |
p values are all against baseline; p values < 0.05 are written in italics.
Values shown are mean ± SD. p values were calculated by Student’s t-test, or Wilcoxon test, as appropriate.
ART, antiretroviral therapy; SD, standard deviation; NNRTIs, non-nucleoside reverse transcriptase inhibitor; INSTIs, integrase strand transfer inhibitors; TC total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; Lipoprotein(a), Lp(a); TC/HDL-C ratio, total cholesterol/high-density lipoprotein-cholesterol ratio.