FIGURE 6.

(a) KEGG pathway enrichment analyses of ZNF687‐related genes by WebGestalt database suggested a relation to PIP3 activating the AKT signaling pathway. (b–e) Quantification of AKT, p‐AKT^Thr308, p‐AKT^Ser473, p‐PDK1^Ser241, P‐C‐Raf^Ser259, p‐GSK‐3β^Ser9, and p‐PTEN^Ser38 proteins via western blotting in A549 and H1299 cells. (f, g) Expression of proteins connected to cell growth, migration, and invasion after ZNF687 overexpression was treated with dimethyl sulfoxide (DMSO) or the PI3K inhibitor LY294002 by western blotting. *p < 0.05; **p < 0.01; ***p < 0.001; **** p < 0.0001. ns, nonsignificant.