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. 2023 May 12;2023(5):CD002892. doi: 10.1002/14651858.CD002892.pub6

Summary of findings 3. An intervention in which the focus is on work‐related risk factors on an individual level compared to no intervention/no stress‐reduction interventionfor stress reduction in healthcare workers.

An intervention in which the focus is on work‐related risk factors on an individual level compared to no intervention/no stress‐reduction intervention for stress reduction in healthcare workers
Patient or population: healthcare workers 
Setting: various healthcare settings
Intervention: an intervention in which the focus is on work‐related risk factors on an individual level 
Comparison: No intervention/no stress‐reduction intervention
Outcomes Anticipated absolute effects* (95% CI) № of participants
(studies) Certainty of the evidence
(GRADE) What happens
Effect with an intervention in which the focus is on work‐related risk factors on an individual level
Stress symptoms (follow‐up up to and including 3 months after end of intervention) no effect estimate 87
(3 RCTs) ⊕⊝⊝⊝
Very low 1 The evidence is very uncertain about the short‐term effect of an intervention in which the focus is on work‐related risk factors on stress symptoms.
Stress symptoms (follow‐up > 3 to 12 months after end of intervention) no effect estimate 152
(2 RCTs) ⊕⊝⊝⊝
Very low 2 The evidence is very uncertain about the medium‐term effect of an intervention in which the focus is on work‐related risk factors on stress symptoms.
Stress symptoms (follow‐up >12 months after end of intervention) no effect estimate 161
(1 RCT) ⊕⊝⊝⊝
Very low 2 The evidence is very uncertain about the long‐term effect of an intervention in which the focus is on work‐related risk factors on stress symptoms.
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). 

CI: confidence interval; SMD: standardized mean difference; MD: mean difference
GRADE Working Group grades of evidenceHigh certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

1 The certainty of the evidence was downgraded by three levels for very serious risk of bias (bias arising from the randomisation process and lack of blinding; i.e. performance bias), inconsistency and very serious imprecision (small sample size, the confidence interval includes both a benefit and a harm).

2 The certainty of the evidence was downgraded by three levels for very serious risk of bias (bias arising from the randomisation process and lack of blinding; i.e. performance bias) and very serious imprecision (small sample size, the confidence interval includes both a benefit and no effect).