Mandal 2021.

Study characteristics
Methods	Study design: randomised controlled trial Study grouping: parallel group
Participants	Baseline characteristics Structured Yoga Program Age (mean ± SD): 35 ± 7.9 Sex (N (% female)): 50 (86%) Sample size: 58 Years of experience (mean ± SD): 12.1 + 7.7 Control (wait list) Age (mean ± SD): 32.5 ± 6.8 Sex (N (% female)): 30 (58%) Sample size: 52 Years of experience (mean ± SD): 10.3 + 7.7 Overall Age (mean ± SD): NR Sex (N (% female)): 80 (73%) Sample size: 110 Years of experience (mean ± SD): NR Included criteria: Working at the hospital for at least 1 year. Excluded criteria: We excluded those who were already under pharmacological treatment for any psychiatric disorder at the time of enrolment; having service left for less than a year (from the date of enrolment); any clinical condition that would affect the ability to practice yoga. Pretreatment: the baseline characteristics were comparable in both the groups except sex, where a higher proportion of males were present in the wait‐list group. The main outcome parameters were similar in both groups. As per the per‐protocol analysis the baseline parameters also showed the similar findings. Type of healthcare worker: exclusively in‐service nursing staff working at the hospital Response rate: 97% Compliance rate: 42%
Interventions	Intervention characteristics Structured Yoga Program Type of the intervention: Intervention type 2 ‐ to focus one’s attention away from the experience of stress Description of the intervention: The yoga module which consisted of asana, pranayama, and deep relaxation technique was developed by a committee of yoga physicians and yoga therapists at the institutional yoga facility (Figure 1). We adopted the 5 minutes deep relaxation technique practised in supine position, Shavasana (Corpse Pose) which is an evidence based scientific way to relax the whole body completely within a short amount of time. It is usually, which literally translates to dead body posture. The number of sessions: 24 Duration of each session on average: 50 minutes Duration of the entire intervention: 12 weeks Duration of the entire intervention short vs long: long Intervention deliverer: The yoga therapists were trained professionals who completed their post‐graduation in the subject from reputed yoga institute Intervention form: All the yoga sessions were provided before or after their duty hours. Control (wait list) Type of the intervention: NA Description of the intervention: NA The number of sessions: NA Duration of each session on average: NA Duration of the entire intervention: NA Duration of the entire intervention short vs long: NA Intervention deliverer: NA Intervention form: NA
Outcomes	Perceived Stress Scale (PSS) Outcome type: ContinuousOutcome
Identification	Sponsorship source: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: All the lab investigations were done free of cost for the participants. The necessary requirements were provided from the institution where I work. Country: India Setting: A tertiary care hospital Comments: NR Authors name: Puneet Misra Institution: Centre for Community Medicine, Room No. 30, Centre for Community Medicine, Old OT Block, All India Institute of Medical Sciences Email: doctormisra@gmail.com Address: Ansarinagar East, 110029, Delhi, India Time period: 2018
Notes	Included in analysis 2.1
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "The investigation team collected unpredictable allocation sequence [using computer software and permuted block randomization] generated by a third party not involved in the study. The block size was multiple of 2 and variable in size."
Allocation concealment (selection bias)	Unclear risk	Quote: "After the baseline assessment was over, the sealed opaque envelop at her/his respective enrolment number was opened in front of the participants to maintain the allocation concealment. The participants were allocated in either of the 2 groups; intervention i.e. yoga group or the wait‐listed group." Difficult to judge whether participants and/or investigators could possibly foresee assignment.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Quote: "Masking of the allocated group was not feasible in the study."
Blinding of outcome assessment (detection bias) All outcomes	High risk	Participants were not blinded whereas outcomes are self‐reported.
Incomplete outcome data (attrition bias) All outcomes	High risk	Quote: "Of the 52 participants joining the class, 25 participants discontinued in the first month, 5 participants in the second month and 3 participants in the third month. Therefore, the remaining 19 participants completed the minimum required 20 yoga sessions. At the end of the 12 weeks of follow up, 19 participants of intervention group and 32 participants of wait‐list control group was included in the analysis." Judgement Comment: > 20% loss to follow‐up
Selective reporting (reporting bias)	Unclear risk	No trial registration, nor did we find one online.
Other bias	Low risk	No indication of other sources of bias.