Table 1.
CERAD Total Scores that distinguish cognitively normal performance, MCI, and dementia status from each other (by education categories where available)
| Reference, Study, Country | Age range (years) | Cutpoint | AUC | Sensitivity | Specificity |
|---|---|---|---|---|---|
| [14] Chandler et al., 2005; University of Texas Southwestern (UTSW) Medical Center, Dallas, US (demographic correction factors given for age, education, and sex, in [14] supplement) | |||||
| Dementia free (N = 95) vs prevalent dementia (N = 95) | |||||
| TS1 | 50+ | 77.0 | 0.958 | 93.7 | 92.6 |
| Dementia free (N = 595) vs prevalent aMCI (N = 60) | |||||
| 50+ | 85.1 | 0.823 | 81.4 | 72.6 | |
| Prevalent aMCI (N = 60) vs prevalent AD (N = 95) | |||||
| 50+ | 68.5 | 0.882 | 80.0 | 81.4 | |
| [17] Wolfsgruber et al., 2014; AgeCoDe, Germany (adjusted for age, sex, education) | |||||
| Dementia free (N = 1540) vs prevalent dementia (N = 66) | |||||
| TS1 | 78+ | ≤60 | 0.971 | 92.4 | 91.4 |
| TS2 | 78+ | ≤68 | 0.973 | 97.0 | 87.7 |
| Continued dementia free (N = 1434) vs incident dementia within 18 months (N = 50) | |||||
| TS1 | 78+ | ≤68 | 0.891 | 85.7 | 83.1 |
| TS2 | 78+ | ≤75 | 0.894 | 89.8 | 78.8 |
| [15] Seo et al., 2010; Community residents, S. Korea | |||||
| Dementia free (N = 1336) vs prevalent dementia (N = 583) | |||||
| TS1 | 60+ | 49.5 | 0.970 | 90.1 | 91.8 |
| TS2 | 60+ | 53.5 | 0.972 | 91.6 | 90.6 |
| Dementia free (N = 1336) vs MCI (N = 250) | |||||
| TS1 | 60+ | 59.5 | 0.821 | 79.2 | 71.0 |
| TS2 | 60+ | 66.5 | 0.822 | 84.0 | 64.7 |
| [18] Paajanen et al., 2014; AddNeuroMed (Finland, France, Greece, Italy, Poland, U.K.) Score country-adjusted, cut-points differed by country | |||||
| Dementia free (n=212) vs progressive MCI (n=46) | |||||
| TS1 | <69 | 0.96 | 89 | 84 | |
| TS2 | <74 | 0.96 | 87 | 86 | |
| Progressive MCI (n=46) vs stable MCI (n=155) | |||||
| TS1 | 0.78 | ||||
| TS2 | 0.79 | ||||
| [19] Aguirre-Acevedo et al., 2016; presenilin-1 gene E280A mutation, Colombia | |||||
| Dementia free (N = 1576) plus MCI (N = 46) vs prevalent dementia (N = 76) (also available: scores adjusted by age; and by age + education; comparison for CDR 1 only) |
|||||
| TS1 | 18+ | <58 | 0.994 | 97.4 | 91.9 |
| 0–8 years education | <54 | 98.4 | 96.2 | ||
| >8 years education | <67 | 100.0 | 94.1 | ||
| Dementia free (N = 1576) vs MCI (N = 46) | |||||
| TS1 | 18+ | <69 | 0.862 | 91.3 | 68.7 |
| 0–8 years education | <66 | 91.2 | 56.4 | ||
| >8 years education | <72 | 91.7 | 76.3 | ||
NOTE: Information above has been adapted from tables presented in the references indicated.
Abbreviations: AD = Alzheimer’s disease; AgeCoDe = Ageing, Cognition and Dementia study of primary care patients age 75 years and over in Germany; AUC = area under the curve; aMCI = amnestic mild cognitive impairment; MCI = mild cognitive impairment; SD = standard deviation; Sensitivity = percentage of cases correctly identified; Specificity = percentage of non-cases correctly identified; TS1 = Sum of scores (maximum scores in parentheses) on Verbal Fluency (24), 15-item modified Boston Naming test (15), Word List Learning test (30), Constructional Praxis copy (11), Word List Recall (10), Word List Recognition (10). Total maximum score =100. TS2 = All items of TS1 plus Constructional Praxis recall (11). Total maximum score =111.