TABLE 2.

Agonist-like effect of anti-TcP2β C terminus antibodies^a

Mouse group	Purified antibodies	Antibodies + bisoprolol	Antibodies + atropine
Control	1.08 ± 0.88	NDb	0.4 ± 0.92
B1	2.2 ± 1.16	ND	2.0 ± 1.24
C1	12.8 ± 1.32	0.6 ± 1.16	18 ± 1.56
C2	16.6 ± 1.36	0.6 ± 1.56	21.2 ± 1.4
D1	20.8 ± 1.04	12 ± 1.12	26.8 ± 1.04

^aAnti-TcP2β IgGs from sera were selected from GST–TcP2β–Alu-Gel-S (group B)- or Hist-TcP2β-CFA (group C)-immunized mice and chronically T. cruzi-infected mice (group D). The increase in beating frequency per minute was determined, and the mean ± standard error of the mean of 10 different measurements is shown. Bisoprolol (1 μM) and atropine (1 μM) were added in different experiments. 

^bND, not done.