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. Author manuscript; available in PMC: 2023 May 12.
Published in final edited form as: Nat Rev Chem. 2023 Mar 20;7(5):355–373. doi: 10.1038/s41570-023-00476-z

Fig. 3 |. Chiral detection of small molecules via chromatography and capillary electrophoresis coupled to mass spectrometry.

Fig. 3 |

After sample preparation, small molecules can be enantiomerically separated using a chiral selector, such as a chiral derivatization reagent (CDR), a chiral mobile phase or a chiral stationary phase during chromatography. The small molecules can also be enantioselectively separated using chiral capillary electrophoresis. The enantiomers, which have different retention times, are separated and resolved by mass spectrometry.