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. Author manuscript; available in PMC: 2023 May 12.
Published in final edited form as: Nat Rev Chem. 2023 Mar 20;7(5):355–373. doi: 10.1038/s41570-023-00476-z

Fig. 4 |. Chiral detection of small molecules with NMR spectroscopy and an enzymatic assay.

Fig. 4 |

a, After sample preparation, small molecules, with the addition of chiral derivatization reagents (CDRs), can be enantiomerically resolved using nuclear magnetic resonance (NMR) spectroscopy. The intensity between d and l peaks on the NMR spectrum reflects the enantiomeric excess. b, After sample preparation, enzymatic probes with enantiomeric selectivity are added to samples to form conjugated molecules. Fluorescent imaging of a colorimetric assay is used to determine the concentration of the targeted enantiomers. H0, magnetic field.