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. Author manuscript; available in PMC: 2024 May 25.
Published in final edited form as: Int J Pharm. 2023 Apr 25;639:122974. doi: 10.1016/j.ijpharm.2023.122974

Table 1.

Distribution of MEV-750 in murine tissues.1

Tissue 6 h 12 h 24 h
Male Female Male Female Male Female
Liver 6679±3951 6828±6828 7683±5061 7587±4566 2925±2925 5496±5285
Spleen 47 ± 47 ND 913±484 777±604 ND ND
Pancreas ND ND 82 ± 43 509±489 ND 8491±8491
Lung 1052±970 1326±628 3066±1069 5290±1240 152±152 315±303
Kidneys ND2 ND 1228±743 2341±240 ND ND
Heart 797±514 462±191 361±357 416±244 125±125 175±118
Brain 2580±670 2083±435 139±108 394±289 1882±591 1300±464
Bone 1674±389 1162±415 411±411 153 ± 90 1532±409 620±189
Muscle 406 ± 88 275 ± 67 32 ± 22 48 ± 22 113 ± 41 311±125
eWAT2 313±115 264 ± 73 246 ± 88 78 ± 55 90 ± 67 122±109
BAT2 1113±418 976±658 ND 38 ± 38 347±138 917±825
Thymus 2463±541 3330±329 369±225 322±124 1415±414 2158±958
GI 2472499± 4407905± 219913± 369293± 22346±15314 264562±
1086825 1649237 34725 109890 201517
1

Value are background-corrected fluorescence (arbitrary units; mean ± SEM; N = 4 (except male lungs, N = 3).

2

BAT, brown adipose tissue; eWAT, epididymal white adipose tissue; GI, gastrointestinal tract; ND, not detectable.