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. 2023 May 11;13:7654. doi: 10.1038/s41598-023-33401-x

Table 4.

Validation results for case definitions for hypertension in children 3–18 years of age.

Years of data Algorithm Hospital separations Physician claims Drug records Sensitivity Specificity Positive predictive value Negative predictive value Kappa Area under Receiver operating curve

1

(2016)

N = 888

1 1 or more 1 or more 0.24 (0.16–0.33) 0.99 (0.98–1) 0.74 (0.59–0.9) 0.92 (0.9–0.94) 0.33 (0.23–0.44) 0.62
2 1 or more 2 or more 0.18 (0.1–0.26) 0.99 (0.99–1) 0.77 (0.6–0.95) 0.91 (0.89–0.93) 0.26 (0.16–0.37) 0.59
3 1 or more 1 or more 1 or more 0.51 (0.41–0.61) 0.98 (0.97–0.99) 0.74 (0.63–0.85) 0.94 (0.93–0.96) 0.57 (0.47–0.66) 0.74
4 1 or more 2 or more 1 or more 0.49 (0.39–0.59) 0.98 (0.97–0.99) 0.75 (0.65––0.86) 0.94 (0.93–0.96) 0.56 (0.46–0.65) 0.74
5 1 or more 1 or more 2 or more 0.44 (0.34–0.54) 0.98 (0.97–0.99) 0.73 (0.62–0.85) 0.94 (0.92–0.95) 0.51 (0.41–0.61) 0.71
6 1 or more 2 or more 2 or more 0.38 (0.28–0.48) 0.98 (0.97–0.99) 0.73 (0.61–0.86) 0.93 (0.91–0.95) 0.46 (0.36–0.57) 0.68

2

2015/16

N = 2821

7 1 or more 1 or more 0.24 (0.17–0.3) 0.99 (0.99–1) 0.7 (0.58–0.82) 0.96 (0.95–0.96) 0.34 (0.26–0.42) 0.62
8 1 or more 2 or more 0.19 (0.13–0.25) 1 (0.99–1) 0.72 (0.59–0.85) 0.95 (0.94–0.96) 0.28 (0.2–0.36) 0.59
9 1 or more 1 or more 1 or more 0.42 (0.35–0.5) 0.99 (0.98–0.99) 0.69 (0.6–0.78) 0.97 (0.96–0.97) 0.5 (0.43–0.58) 0.71
10 1 or more 2 or more 1 or more 0.39 (0.32–0.47) 0.99 (0.99–0.99) 0.7 (0.61–0.8) 0.96 (0.96–0.97) 0.48 (0.41–0.56) 0.69
11 1 or more 1 or more 2 or more 0.37 (0.29–0.44) 0.99 (0.99–0.99) 0.7 (0.6–0.79) 0.96 (0.96–0.97) 0.46 (0.38–0.54) 0.68
12 1 or more 2 or more 2 or more 0.34 (0.26–0.41) 0.99 (0.99–1) 0.71 (0.61–0.82) 0.96 (0.95–0.97) 0.44 (0.36–0.52) 0.66

3

14/15/16

N = 4331

13 1 or more 1 or more 0.22 (0.17–0.28) 0.99 (0.99–1) 0.65 (0.55–0.75) 0.96 (0.95––0.96) 0.31 (0.25–0.38) 0.61
14 1 or more 2 or more 0.19 (0.14–0.24) 1 (0.99–1) 0.7 (0.59–0.81) 0.95 (0.95–0.96) 0.28 (0.22–0.35) 0.59
15 1 or more 1 or more 1 or more 0.39 (0.33–0.45) 0.99 (0.98–0.99) 0.66 (0.58–0.74) 0.96 (0.96–0.97) 0.47 (0.41–0.53) 0.69
16 1 or more 2 or more 1 or more 0.37 (0.3–0.43) 0.99 (0.99–0.99) 0.69 (0.61–0.77) 0.96 (0.96–0.97) 0.46 (0.39–0.52) 0.68
17 1 or more 1 or more 2 or more 0.33 (0.27–0.39) 0.99 (0.99–0.99) 0.65 (0.56–0.73) 0.96 (0.96–0.97) 0.42 (0.35–0.48) 0.66